Recruiting

Talc Pleurodesis for Malignant Pleural Effusion on Outpatient Basis

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What is being tested

ambulatory chest drain and talc pleurodesis

Procedure
Who is being recruted

Neoplasms+6

+ Neoplasms by Site

+ Pleural Diseases

Over 18 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: January 2024
See protocol details

Summary

Principal SponsorDavid Rollins
Study ContactKevin Conroy, MBBS, FRCP
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 10, 2024

Actual date on which the first participant was enrolled.

This clinical trial investigates whether a procedure known as talc pleurodesis can be effectively performed on an outpatient basis for patients with malignant pleural effusion, which is a condition where fluid builds up around the lungs due to cancer. By performing the procedure outside of the hospital, the study aims to make treatment more convenient for patients and potentially reduce hospital stays and associated costs. The trial targets patients who are eligible for this procedure and offers them a chance to participate in the study in addition to receiving standard care options. During the study, participants undergo a process starting on the first day where a chest drain is inserted to remove fluid from the chest cavity. The fluid is drained in stages throughout the day, and patients go home with a special bag to collect any remaining fluid. On the second day, if the fluid removal is successful and the lung is fully expanded, talc is introduced into the chest to prevent fluid from accumulating again, and the process of draining and monitoring continues. By the third day, if the fluid accumulation has resolved, the drain is removed, and the success of the procedure is confirmed with a chest x-ray. Participants are also asked to fill out short questionnaires regarding their breathing, pain levels, and overall satisfaction with the procedure, which helps measure the trial's success.

Official TitleCan Talc Pleurodesis for Malignant Pleural Effusion be Performed on an Ambulatory Basis
NCT06682936
Principal SponsorDavid Rollins
Study ContactKevin Conroy, MBBS, FRCP
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

15 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

NeoplasmsNeoplasms by SitePleural DiseasesPleural EffusionPleural NeoplasmsRespiratory Tract DiseasesRespiratory Tract NeoplasmsThoracic NeoplasmsPleural Effusion, Malignant

Criteria

3 inclusion criteria required to participate
Malignant pleural effusion

Life expectancy >30 days

WHO PS 1-2 (3 if due to dyspnoea)

2 exclusion criteria prevent from participating
Previous failed pleurodesis (on affected side)

Known non-expansile lung

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Patients enrolled to the trial will have a chest drain inserted and we will aim to drain to dryness and instill medical grade talc as described in the protocol

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

North Tees and Hartlepool NHS foundation trust

Stockton-on-Tees, United KingdomOpen North Tees and Hartlepool NHS foundation trust in Google Maps
Recruiting
One Study Center