Recruiting

HyperSight CBCT Imaging for Enhanced Radiotherapy in Cancer Patients

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What is being tested

Comparison of HyperSight CBCT imaging to conventional CBCT imaging.

Device
Who is being recruted

Urogenital Diseases+15

+ Breast Diseases

+ Breast Neoplasms

Over 18 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: February 2025
See protocol details

Summary

Principal SponsorVarian, a Siemens Healthineers Company
Study ContactSean Davidson
Last updated: March 14, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 19, 2025

Actual date on which the first participant was enrolled.

This study focuses on testing a new imaging technology called HyperSight, designed to improve the quality of images used during radiation therapy for cancer patients. Traditional cone beam computed tomography (CBCT) systems help position patients accurately for their daily treatments but often produce images with poor contrast and artifacts, limiting their usefulness for other purposes. HyperSight, developed by Varian Medical Systems, aims to overcome these limitations, potentially enhancing the overall radiation therapy process. The study's goal is to assess whether HyperSight can provide higher quality images that could assist in creating more precise radiation plans. Participants in this study will undergo imaging using the HyperSight-TrueBeam system, which utilizes a rotating C-shaped arm to capture images of different body areas. The collected images will be carefully evaluated to see if they offer better clarity and detail compared to traditional CBCT images. By measuring the quality of the HyperSight images, the study aims to determine if they can be used for more than just patient alignment, such as calculating radiation treatment plans. There are no specified risks or benefits mentioned, but the potential for improved treatment accuracy could offer significant advantages for cancer patients.

Official TitleA Feasibility Study of a Novel Cone-Beam CT Approach for Image Guided Radiotherapy in Cancer Patients
NCT06681233
Principal SponsorVarian, a Siemens Healthineers Company
Study ContactSean Davidson
Last updated: March 14, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesBreast DiseasesBreast NeoplasmsDigestive System DiseasesDigestive System NeoplasmsFemale Urogenital Diseases and Pregnancy ComplicationsGastrointestinal DiseasesGastrointestinal NeoplasmsHead and Neck NeoplasmsLiver DiseasesLiver NeoplasmsNeoplasmsNeoplasms by SiteSkin DiseasesUrogenital NeoplasmsSkin and Connective Tissue DiseasesFemale Urogenital DiseasesMale Urogenital Diseases

Criteria

3 inclusion criteria required to participate
Patient is receiving radiation therapy for head and neck, thorax, liver, breast, genitourinary, or gastrointestinal malignancies

A CBCT acquisition for localization is standard of care for the radiation therapy treatment plan being delivered

Patient age >= 18

6 exclusion criteria prevent from participating
Patient is wheelchair bound

Patient has ECOG Performance Status >= 3

Patient is part of a vulnerable population (per ISO 14155:2020, "individuals who are unable to fully understand all aspects of the investigation that are relevant to the decision to participate, or who could be manipulated or unduly influenced as a result of a compromised position, expectation of benefits or fear of retaliatory response"). This includes prisoners

Patient is pregnant or has plans for pregnancy during the period of treatment

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 4 locations

Recruiting

James Outpatient Center

Columbus, United StatesOpen James Outpatient Center in Google Maps
Recruiting

Ohio State University, Brain and Spine Hospital

Columbus, United States
Recruiting

The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Columbus, United States
Recruiting

Stefanie Spielman Comprehensive Breast Center

Columbus, United States
Recruiting
4 Study Centers