Completed

CONCRET-MENOPACreatine Supplements for Cognitive Performance in Menopausal Women

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Dietary Supplement: Experimental 1 Creatine HCl

+ Dietary Supplement: Experimental 2 Creatine HCl

+ Dietary Supplement: Experimental 3 Creatine Ethyl ester

Dietary Supplement
Who is being recruted

Fatigue

+ Signs and Symptoms

+ Pathological Conditions, Signs and Symptoms

From 40 to 65 Years
See all eligibility criteria
How is the trial designed

Supportive Care Study

Placebo-Controlled
Interventional
Study Start: November 2024
See protocol details

Summary

Principal SponsorUniversity of Novi Sad, Faculty of Sport and Physical Education
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 15, 2024

Actual date on which the first participant was enrolled.

This study is designed to explore how supplements like creatine HCl and creatine ethyl ester can affect the brain and body functions of women who are going through or have completed menopause. The research focuses on understanding changes in mental capabilities, levels of tiredness, brain health, and certain biochemical markers. Such studies are important because women in this stage of life often experience changes in these areas, and finding effective supplements could improve their quality of life. Participants in the study will receive either creatine HCl or creatine ethyl ester supplements. These supplements are administered in a controlled manner, ensuring neither the participants nor the researchers know who is receiving which type. The effects on cognitive abilities, fatigue, brain metabolism, and biochemical markers will be closely monitored and evaluated. This approach helps ensure that any observed changes are due to the supplements and not other factors, aiming to provide clear insights into the potential benefits or risks of these dietary additions.

Official TitleThe Effects of 8-Week Creatine HCl and Creatine Ethyl Ester Supplementation on Cognitive Performance, Multidimensional Fatigue, Brain Metabolism, and Biochemical Indices in Perimenopausal and Menopausal Women
Principal SponsorUniversity of Novi Sad, Faculty of Sport and Physical Education
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

36 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 40 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

FatigueSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

Inclusion Criteria: * Body mass index 18.5 - 29.9 kg/m2 * Free of major chronic diseases or acute disorders (including AD and dementia (MMSE score \> 25 points) * MENOPAUSAL: no menstrual cycle for consecutive 12 months (with no other obvious causes) * PERIMENOPAUSAL: Still menstruating (regular or irregular) but have at least one of the following symptoms: (1) hot flashes, (2) sleep disturbances, (3) mood swings, and (4) concentration difficulties * Given written informed consent Exclusion Criteria: * History of dietary supplement use 4 weeks before the study commences * Pregnancy (or planning pregnancy) * Abnormal values for lab clinical chemistry (\> 2 SD) * Unwillingness to return for follow-up analysis * Participation in other clinical trials

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

25% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
One capsule per day of creatine hcl during breakfast

Group II

Experimental
One capsule during breakfast and one during dinner of creatine hcl

Group III

Experimental
One capsule during breakfast and one during dinner of creatine ethyl ester

Group IV

Placebo
One capsule per day of inulin during breakfast

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

FSPE Applied BIoenergetcis Lab

Novi Sad, SerbiaOpen FSPE Applied BIoenergetcis Lab in Google Maps
CompletedOne Study Center
CONCRET-MENOPA | Creatine Supplements for Cognitive Performance in Menopausal Women | PatLynk