Levofloxacin with Metronidazole Suppositories for Chronic Endometritis

Chronic endometritis is a condition where the lining of the uterus becomes inflamed, often due to infections. This inflammation can lead to difficulties in getting pregnant, miscarriages, and issues with carrying a pregnancy to term. Current treatments usually involve taking antibiotics by mouth, but these can have side effects like nausea and skin rashes, and sometimes they don't work as well as hoped. This study is looking at whether treating the condition with a combination of levofloxacin and metronidazole in different forms might be more effective. The researchers are testing if using metronidazole as a suppository, which is inserted into the vagina, can deliver the medicine more directly to the problem area and improve pregnancy outcomes for women with this condition. In this study, participants are randomly assigned to receive either the standard treatment of oral levofloxacin and metronidazole tablets or a combination of levofloxacin with metronidazole suppositories. The focus is on women aged 20 to 42 who have been diagnosed with chronic endometritis through specific medical procedures. By comparing the pregnancy success rates between these two groups, the study aims to find a better treatment method that could help improve the chances of getting pregnant and having a successful birth. Participants need to have certain health criteria met, and those with other specific medical conditions or allergies to the medications used are not included in the study.