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3D VR and Indocyanine Green for Pulmonary Segmental Resection in NSCLC

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What is being tested

3-Dimensional VR Modelling (Elucis) with Intravascular Indocyanine Green Fluorescence Mapping

+ 3-Dimensional Modelling (Synapse 3D) with Intravascular Indocyanine Green Fluorescence Mapping

Device
Who is being recruted

Bronchial Neoplasms+7

+ Carcinoma, Bronchogenic

+ Carcinoma, Non-Small-Cell Lung

Over 18 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1 & 2
Interventional
Study Start: December 2026
See protocol details

Summary

Principal SponsorSt. Joseph's Healthcare Hamilton
Study ContactYogita S Patel
Last updated: February 3, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 1, 2026

Actual date on which the first participant was enrolled.

This clinical trial is focused on improving a surgical technique called segmental resection for patients with early-stage non-small cell lung cancer (NSCLC). Typically, this type of surgery is very challenging due to the complex and varying anatomy of the lungs. It is difficult for surgeons to clearly see and separate the different parts of the lung during the operation. The current success rate for completing this surgery is about 60%, which is quite low. The study aims to enhance this procedure using 3-dimensional virtual reality (VR) modelling to help plan and conduct the surgery more effectively. The goal is to make this technique more successful and widely usable by more surgeons. Participants in this study will undergo segmental resection surgery with the aid of advanced technology. The study uses 3D VR models to plan the surgery, providing a clearer view of the lung's anatomy before and during the operation. Additionally, a special imaging technique using a substance called Indocyanine Green (ICG) is used to help map out the lung segments more accurately during surgery. This trial is in its early stages, known as Phase I, and aims to assess how safe and feasible this approach is and how quickly surgeons can learn to use this new technology. The study does not outline specific risks or benefits but focuses on improving the precision and success rate of lung surgeries.

Official Title3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial
NCT06638125
Principal SponsorSt. Joseph's Healthcare Hamilton
Study ContactYogita S Patel
Last updated: February 3, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

89 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bronchial NeoplasmsCarcinoma, BronchogenicCarcinoma, Non-Small-Cell LungLung DiseasesLung NeoplasmsNeoplasmsNeoplasms by SiteRespiratory Tract DiseasesRespiratory Tract NeoplasmsThoracic Neoplasms

Criteria

4 inclusion criteria required to participate
Age >/= 18 years

Tumour size < 3 cm

Clinical Stage 1 Non-Small Cell Lung Cancer (NSCLC)

CT-imaging confirming that the tumour is confined to one broncho-pulmonary segment, rendering the patient a candidate for segmental resection.

2 exclusion criteria prevent from participating
Hypersensitivity or allergy to ICG, sodium iodide, or iodine

Women who are currently pregnant or breastfeeding; or women of childbearing potential who are not currently taking adequate birth control.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
All patients in Phase I and those randomized to Intervention in Phase II will have preoperative 3D VR reconstructions of their pulmonary anatomy with the target lesion created using the Elucis platform.

Group II

Active Comparator
The patients that are randomized to Control in Phase II will undergo the same intervention as above, but instead of using Elucis for 3D VR reconstructions, Synapse 3D will be used for 3D reconstructions.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

St. Joseph's Healthcare Hamilton

Hamilton, CanadaOpen St. Joseph's Healthcare Hamilton in Google Maps
Recruiting soonOne Study Center