Recruiting

NMN Supplementation for IVF Failure Patients

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

NMN capsule

+ Placebo

Dietary SupplementOther
Who is being recruted

Urogenital Diseases+4

+ Genital Diseases

+ Female Urogenital Diseases and Pregnancy Complications

From 32 to 42 Years
+18 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Placebo-Controlled
Interventional
Study Start: August 2024
See protocol details

Summary

Principal SponsorSunkaky Medical Cooperation
Study ContactUdayanga KGS., Udayanga Gamage, BVSc, PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 20, 2024

Actual date on which the first participant was enrolled.

This clinical study focuses on improving the chances of success for people undergoing in vitro fertilization (IVF) who have faced previous failures. It investigates the use of a compound called Nicotinamide mononucleotide (NMN), which has shown promise in enhancing the quality of eggs in older individuals by supporting energy production and reducing cellular damage. The study is important because recurrent IVF failures can have significant emotional and financial impacts, and finding effective ways to improve egg quality may enhance the success rate of these fertility treatments. Participants in this study will take part in a trial where they are randomly assigned to receive either the NMN supplement or a placebo, without knowing which one they are getting, to ensure unbiased results. The supplement is given orally in a daily dose of 900 mg. Researchers will monitor the effects of NMN on IVF outcomes by evaluating the quality of eggs and embryos. The study aims to determine if NMN can indeed improve the chances of successful fertilization and pregnancy for those who have previously experienced challenges with IVF.

Official TitleInvestigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures.
NCT06629636
Principal SponsorSunkaky Medical Cooperation
Study ContactUdayanga KGS., Udayanga Gamage, BVSc, PhDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 32 to 42 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsGenital Diseases, FemaleInfertilityInfertility, FemaleFemale Urogenital Diseases

Criteria

6 inclusion criteria required to participate
Agree to participate in the study

32-42 years old

Having at least one previous embryo implantation failure

History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria)

Show More Criteria

12 exclusion criteria prevent from participating
Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4)

Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month

Any medical contraindication of oocyte retrieval or subsequent procedures

Couples where the husband presents with severe sperm abnormalities

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
NMN capsules (total of 900mg/day) for 8 weeks

Group II

Placebo
NMN-free placebo capsules for 8 weeks

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

IVF Namba Clinic, Sankaky Medical Corporation

Osaka, JapanOpen IVF Namba Clinic, Sankaky Medical Corporation in Google Maps
Recruiting
One Study Center