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Cilostazol Impact on Cognitive and Motor Symptoms in Parkinson's Disease

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What is being tested

Cilostazol

+ Standard treatment

+ Placebo

Drug
Who is being recruted

Synucleinopathies+10

+ Neuroinflammatory Diseases

+ Basal Ganglia Diseases

+14 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: October 2024
See protocol details

Summary

Principal SponsorAin Shams University
Study ContactAlia Hassan Mansour, Ph.D., MD.
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 1, 2024

Actual date on which the first participant was enrolled.

This clinical trial is focused on evaluating the effects of the drug Cilostazol on patients with Parkinson's Disease. Parkinson's Disease is a progressive brain disorder that affects movement and can lead to cognitive decline. The disease is associated with the degeneration of dopamine-producing neurons and is influenced by factors like inflammation and oxidative stress. Cilostazol, which is already used to treat certain vascular conditions, has properties that could potentially protect brain cells by reducing inflammation and oxidative stress. This study is investigating whether Cilostazol can help slow down the progression of Parkinson's Disease and improve cognitive function in patients. Participants in the trial will receive Cilostazol, typically administered in pill form, to assess its impact on Parkinson's Disease symptoms and cognitive decline. The study will measure various outcomes, such as improvements in movement and cognitive abilities, to determine the drug's effectiveness. While Cilostazol has shown promise in preliminary studies, it is important to monitor for potential side effects, which can include headaches and gastrointestinal issues, among others. The goal of the study is to explore a novel treatment option that might offer better management of Parkinson's Disease symptoms and potentially slow its progression.

Official TitleThe Effect of Cilostazol on the Clinical Outcome of Patients with Parkinson's Disease
NCT06612593
Principal SponsorAin Shams University
Study ContactAlia Hassan Mansour, Ph.D., MD.
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

SynucleinopathiesNeuroinflammatory DiseasesBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesInflammationMovement DisordersNervous System DiseasesParkinson DiseasePathologic ProcessesPathological Conditions, Signs and SymptomsNeurodegenerative DiseasesParkinsonian Disorders

Criteria

6 inclusion criteria required to participate
Adult patients.

Both males and females will be included

Diagnosed Parkinson's disease according to the MDS criteria 2015

At least 5 years of disease duration

Show More Criteria

8 exclusion criteria prevent from participating
Secondary causes of Parkinsonism

Atypical parkinsonian syndromes

Active malignancy

Known intolerance or hypersensitivity to cilostazol

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
25 participants will receive the standard treatment and cilostazol at a dose of 50 mg twice daily for a month, then the dose will be increased to 100 mg twice daily for 5 months.

Group II

Active Comparator
25 participants will receive the standard treatment and the placebo twice daily for 6 months.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Ain Shams University Hospital

Cairo, EgyptOpen Ain Shams University Hospital in Google Maps
Recruiting soonOne Study Center