BUPARDEXNSAID Steroid Therapy for Pain Relief After Kidney Stone Surgery

This study is exploring how a combination of medications can help control pain and inflammation after a kidney stone removal surgery called percutaneous nephrolithotomy. By focusing on patients who undergo this procedure, researchers aim to find out if using NSAID steroid therapy affects the levels of a substance called PGE2, which is linked to inflammation, as well as how effective the therapy is at managing pain. This is important because controlling pain and inflammation effectively can improve recovery and comfort for patients after surgery. Participants in this study are divided into three groups, each receiving a different set of medications through an intravenous (IV) route. One group receives ibuprofen, paracetamol, and dexamethasone, another group receives ibuprofen, paracetamol, and a placebo, and the last group receives paracetamol with two placebos. These medications are given during surgery and eight hours after the first dose. The study measures the level of PGE2 in the blood and uses a numeric rating scale to assess pain relief. Additionally, any side effects from the medications are monitored to ensure safety. This approach helps determine the best method for managing pain and inflammation post-surgery.