Dexamethasone for Pain, Edema, and Trismus After Wisdom Tooth Surgery
In this group, patients received 8 mg IM dexamethasone injection into the masseter muscle after impacted tooth surgery.
+ 8 mg IM dexamethasone injection into the pterygoid cavity after impacted tooth surgery.
Edema+9
+ Nervous System Diseases
+ Neurologic Manifestations
Treatment Study
Summary
Study start date: April 28, 2023
Actual date on which the first participant was enrolled.This study is investigating how to reduce common side effects such as pain, swelling, and difficulty opening the mouth after surgery to remove impacted lower wisdom teeth. The focus is on using a steroid called dexamethasone, which is injected directly into specific muscles around the jaw area immediately after the tooth is removed. The study involves patients who are 18 years or older and have wisdom teeth that are difficult to extract. By finding out which injection site is more effective, this research aims to improve recovery outcomes for people undergoing similar dental procedures. Participants in the study will have their impacted wisdom teeth removed two weeks apart. After each tooth extraction, dexamethasone is injected into different areas of the jaw to compare effects. The study will assess pain levels, swelling, and mouth opening ability through various measurements and questionnaires. These assessments will take place at multiple times, including the day of the procedure and on the 3rd and 7th days afterward. Although complications are rare, potential risks include allergic reactions, infection, or temporary numbness. The study is one month long for each participant, and it is important to attend follow-up appointments and report any issues during the study.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.20 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 25 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * 1\. Patients with no systemic disease, AAD (American Society of Anesthesiologists) class I and BMI (body mass index) below 30. 2\. Patients between the ages of 18-25 with bilaterally symmetrical and mesioangularly positioned impacted third molars in the mandible. 3\. Patients with impacted mandibular third molars in class II-B according to the Pell and Gregory classification. 4\. Patients with impacted third molars that are fully or partially retained and asymptomatic. 5\. Patients with impacted mandibular third molars that are not associated with any pathology such as cysts or tumors and do not have active perichronitis. 6\. Patients with at least 2/3 of root development completed. 7\. Patients without complaints such as active caries, periodontal disease, pain or swelling in the operation area. 8\. Patients without a history of infection or perichronitis in the operation area. Exclusion Criteria: * 1\. Patients with a history of allergy to dexamethasone or other drugs to be used in the study. 2\. Patients with systemic bacterial, viral, and fungal infections. 3\. Breastfeeding mothers. 4\. Patients with diagnosed or suspected pregnancies. 5\. Patients in whom corticosteroids are contraindicated. 6\. Patients who have recently been treated with anti-inflammatory drugs. 7\. Patients with cardiovascular disease. 8\. Patients with acute or chronic maxillary sinusitis. 9\. Patients who are taking medications such as antidepressants or antihistamines on a regular basis. 10\. Patients with psychiatric problems. 11\. Patients with diabetes mellitus, rheumatic diseases, hematological diseases, or liver diseases. 12\. Patients at risk of effective endocarditis. 13\. Patients who smoke. 14\. Patients who use oral contraceptives.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
Active ComparatorStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Afyonkarahisar Health Sciences University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery
Afyonkarahisar, Turkey (Türkiye)Open Afyonkarahisar Health Sciences University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery in Google Maps