Recruiting

Modified Guarnieri-Desarda vs. Lichtenstein Technique for Inguinal Hernia Repair

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What is being tested

Lichtenstein Mesh-Based Hernioplasty

+ Combined Modified Guarnieri-Desarda Tissue-Based Hernioplasty

Procedure
Who is being recruted

Hernia+2

+ Hernia, Inguinal

+ Pathological Conditions, Signs and Symptoms

Over 18 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: October 2024
See protocol details

Summary

Principal SponsorCairo University
Study ContactFadi F. Khalil, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 10, 2024

Actual date on which the first participant was enrolled.

This study aims to compare two different surgical methods for repairing inguinal hernias, which are bulges in the lower abdomen or groin. The two techniques being compared are the Lichtenstein tension-free mesh hernioplasty and a modified version of the Guarnieri-Desarda technique. The study focuses on several important factors such as how much pain patients experience after surgery, any complications like fluid build-up or infections, and the risk of the hernia coming back. It also looks at the health of the testicles by using ultrasound technology to check blood flow and size. This research is important as it could help determine which surgical method might be more effective and comfortable for patients. Participants in this study will undergo one of the two surgical techniques for hernia repair. After the surgery, doctors will monitor them for pain levels, any complications, and the possibility of the hernia returning. The study uses a testicular duplex and ultrasound to evaluate the effects of surgery on testicular health. Monitoring will help understand the impact of each technique on blood flow and size of the testicles. By comparing these factors, the study will identify which method provides better outcomes for patients, potentially leading to improved surgical options in the future.

Official TitleComparative Study of Modified Guarnieri-Desarda Technique Versus Lichtenstein Technique in Inguinal Hernia Repair
NCT06595628
Principal SponsorCairo University
Study ContactFadi F. Khalil, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HerniaHernia, InguinalPathological Conditions, Signs and SymptomsPathological Conditions, AnatomicalHernia, Abdominal

Criteria

3 inclusion criteria required to participate
Adult male patients aged 18 years or older.

Patients diagnosed with non-complicated inguinal hernia (both direct and indirect).

Patients able to provide written informed consent to participate in the study.

6 exclusion criteria prevent from participating
Patients younger than 18 years old.

Patients with complicated hernias (e.g., inflamed, obstructed, or strangulated hernias).

Patients with a recurrent inguinal hernia.

Patients with weak or thin external oblique aponeurosis (intraoperative findings).

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Participants in this arm will undergo the Lichtenstein tension-free hernioplasty, which involves reinforcing the inguinal canal floor using a synthetic mesh. The mesh is fixed to the inguinal ligament and internal oblique aponeurosis, minimizing tension in the repair and reducing the risk of recurrence.

Group II

Experimental
Participants in this arm will receive the combined modified Guarnieri-Desarda tissue-based repair. This approach involves reconstructing the inguinal canal without the use of synthetic mesh, using the patient's own tissues to reinforce the canal and reduce tension. The technique combines aspects of both the Guarnieri and Desarda methods, aiming to preserve the natural physiology of the inguinal canal while providing tension-free repair.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Kasralainy

Cairo, EgyptOpen Kasralainy in Google Maps
Recruiting
One Study Center