Recruiting soon

Mouthwash Effects on Healing After Tooth Extraction

What is being tested

Chlorhexidine Gluconate

+ Bone Bioactive Liquid

+ Hyaluronic Acid mouthwash

Drug

Who is being recruted

Pathologic Processes

+ Postoperative Complications

+ Pathological Conditions, Signs and Symptoms

Over 18 Years

+12 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Supportive Care Study

Phase 4

Interventional

Study Start: January 2025

See protocol details

Summary

Principal SponsorUniversity of Jordan

Study ContactAhmad Hamdan, Ph.D. in Periodontics

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: January 2, 2025

Actual date on which the first participant was enrolled.

This clinical trial aims to determine how different types of mouthwash influence the healing process after removing a wisdom tooth from the lower jaw. It targets adults aged 18 and older who require the extraction of an impacted mandibular third molar. By comparing the effects of four specific mouthwashes—Bone Bioactive Liquid, Hyaluronic Acid, Chlorhexidine digluconate, and a Warm Saline Mouth Rinse—the study seeks to identify the best option for promoting healing and improving patients' quality of life following surgery, which is a significant concern for many undergoing such procedures. Participants are divided into four groups, each receiving a different mouthwash to use after their tooth extraction. The study observes how each mouthwash affects the healing of the extraction site and evaluates other factors related to the patients' recovery experience. This will help in understanding which mouthwash provides the most benefits in terms of both physical healing and overall well-being after dental surgery. The trial does not mention specific risks, but the aim is to find the most effective mouthwash with the least side effects for patients.

Official TitleA Randomized Controlled Trial on the Effect of Different Types of Mouthwash on the Healing of Extraction Sockets

NCT06587880

Principal SponsorUniversity of Jordan

Study ContactAhmad Hamdan, Ph.D. in Periodontics

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Pathologic ProcessesPostoperative ComplicationsPathological Conditions, Signs and Symptoms

Criteria

1 inclusion criteria required to participate

Male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar.

11 exclusion criteria prevent from participating

Soft tissue impaction that will not need any bone removal.

Presence of any acute oral infection including active Pericoronitis.

Patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment.

Patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

4 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Active Comparator

It is a strong bisbiguanide base, with cationic structure at physiological pH (positively charged), and has a broad-spectrum antibacterial activity that works against Gram-positive and Gram- negative bacteria and certain mycetes.

Group II

Active Comparator

Bone bioactive liquid (BBL) is a saline solution used as a mouthwash that contains calcium chloride (CaCl2) and magnesium dichloride hexahydrate (MgCl2-6H2O) with a net negative charge.

Group III

Active Comparator

It is a high molecular weight non-sulphated polysaccharide. It is biocompatible, non-immunogenic, biodegradable, viscoelastic that make it a preferable biomaterial for medical and pharmaceutical applications without adverse events.

Group IV

Active Comparator

Prescribing WSMR as a prophylactic postoperatively is due to the fact that the heat of the solution results in a therapeutic increase in blood flow to the extraction socket.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Jordan hospital

Amman, JordanOpen University of Jordan hospital in Google Maps

Recruiting soonOne Study Center