Probiotics and Activated Charcoal for Uremic Pruritus in Chronic Kidney Disease

Chronic kidney disease-associated pruritus is an uncomfortable condition that leads to a persistent need to scratch, significantly affecting the quality of life for those with chronic kidney disease. This study aims to explore whether probiotics or activated charcoal can help manage this skin itching problem. By investigating ways to reduce the levels of certain toxins in the body that contribute to this itchiness, this study hopes to find more effective treatments. Probiotics might help by improving the balance of good bacteria in the body, while activated charcoal may work by absorbing these toxins before they get into the bloodstream. Participants in this study will receive either probiotics or activated charcoal. Probiotics are taken orally and work by enhancing the gut's bacterial environment, potentially leading to improvements in skin conditions. Activated charcoal, also taken orally, acts by capturing toxins within the digestive system, thus reducing their levels in the blood. The effectiveness of these treatments will be evaluated based on how much they can reduce the sensation of itching and improve the participants' overall quality of life. Both treatments are being tested for their ability to offer relief without causing serious side effects.