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Electroacupuncture Waveforms for Subacute Peripheral Facial Paralysis

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What is being tested

low-frequency continuous wave EA

+ discontinuous wave EA

+ dilatational wave EA

Other
Who is being recruted

Cranial Nerve Diseases+12

+ DNA Virus Infections

+ Facial Nerve Diseases

From 18 to 65 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: November 2024
See protocol details

Summary

Principal SponsorThe Third Affiliated hospital of Zhejiang Chinese Medical University
Study ContactJing Sun, Ph.DMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 15, 2024

Actual date on which the first participant was enrolled.

This study aims to explore the effectiveness of electroacupuncture with different waveforms in treating subacute peripheral facial paralysis. The trial involves seventy-five patients who will be treated at outpatient clinics in three hospitals in China. Participants will be divided into three groups, each receiving a specific type of electroacupuncture waveform: low frequency continuous, discontinuous, and dilatational waves. The study is important because it seeks to identify the most effective waveform, potentially leading to better treatment options for people experiencing facial paralysis, which can significantly affect their quality of life. Participants in the study will receive traditional acupuncture at specific points on the face and additional electroacupuncture treatment for 20 minutes, three times a week, over four weeks. The effectiveness of the treatments will be assessed using the Facial Nerve Grading System 2.0 at the start and end of the four-week period. Secondary measures include the Sunnybrook facial grading system, the Facial Disability Index Scale, and an amplitude ratio test of the affected and healthy sides using ENoG. These assessments will help determine improvements in facial movement and disability. The study will provide insights into the potential benefits and effectiveness of different electroacupuncture waveforms for facial paralysis treatment.

Official TitleTreatment of Electroacupuncture with Different Waveform for Subacute Peripheral Facial Paralysis:study Protocol for a Randomized Controlled Trial
NCT06573697
Principal SponsorThe Third Affiliated hospital of Zhejiang Chinese Medical University
Study ContactJing Sun, Ph.DMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

75 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cranial Nerve DiseasesDNA Virus InfectionsFacial Nerve DiseasesFacial ParalysisHerpesviridae InfectionsInfectionsStomatognathic DiseasesMouth DiseasesNervous System DiseasesNeurologic ManifestationsParalysisSigns and SymptomsPathological Conditions, Signs and SymptomsVirus DiseasesBell Palsy

Criteria

5 inclusion criteria required to participate
Patients meet the clinical classification criteria for BP, diagnosed by specialist.

1-3 weeks from onset.

Male or female patients aged 18-65 years.

FNGS2.0≥4

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7 exclusion criteria prevent from participating
Facial paralysis due to other causes, such as stroke, Guillain-Barre syndrome, multiple sclerosis, encephalitis, facial nerve tumors, skin tumors, parotid tumors, and facial nerve trauma;.

Patients with Hunter's syndrome.

Patients with bilateral facial nerve palsy.

Patients with hemifacial spasm as the the main clinical symptoms.

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
In each treatment session, the patients will receive EA treatment. The selected acupoints for needling will be BL2, GB1, GB14, ST2, SI18, ST6, ST4, ST7, SJ17, EX-HN16, EX-HN5, on affected side, and LI4, bilaterally. After the de-qi sensation is achieved, electrical stimulator will be connected to BL2-GB1, and ST4-ST6, and 2Hz continuous wave will be used for 20 min.

Group II

Experimental
In each treatment session, the patientss will receive EA treatment. The selected acupoints for needling will be BL2, GB1, GB14, ST2, SI18, ST6, ST4, ST7, SJ17, EX-HN16, EX-HN5, on affected side, and LI4, bilaterally. After the de-qi sensation is achieved, electrical stimulator will be connected to BL2-GB1, and ST4-ST6, and 40Hz discontinuous wave will be used for 20 min.

Group III

Experimental
In each treatment session, the patientss will receive EA treatment. The selected acupoints for needling will be BL2, GB1, GB14, ST2, SI18, ST6, ST4, ST7, SJ17, EX-HN16, EX-HN5, on affected side, and LI4, bilaterally. After the de-qi sensation is achieved, electrical stimulator will be connected to BL2-GB1, and ST4-ST6, and 2/100Hz dilatational wave will be used for 20 min.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The Third Affiliated hospital of Zhejiang Chinese Medical University

Hangzhou, ChinaOpen The Third Affiliated hospital of Zhejiang Chinese Medical University in Google Maps
Recruiting soonOne Study Center