Protein-bound Toxin Removal with High-flux Dialyzer in Hemodialysis

This study focuses on comparing two different kidney dialysis methods to see how well they remove certain toxins from the blood. These toxins are usually bound to proteins or are large molecules, and removing them is important for people with kidney issues. The study aims to understand which method, between hemodialysis and high-volume online hemodiafiltration, is more effective in clearing these toxins. This research is important because finding a more efficient way to clean the blood can improve the health and quality of life for patients undergoing dialysis. Participants in this study will undergo both types of dialysis methods, in a crossover manner, meaning they will switch from one method to the other during the study. The researchers will measure various outcomes, including the reduction of Beta2microglobulin and other specific proteins, as well as checking for any loss of important blood proteins like albumin. Additionally, the study will look at how these treatments affect the patients' quality of life, muscle mass, and nutritional status. Understanding these effects will help in determining the most beneficial dialysis method for patients.