Completed

Clomiphene Citrate for Idiopathic Oligoasthenozoospermia in Infertile Men

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Clomiphene Citrate

+ Placebo

Drug
Who is being recruted

Urogenital Diseases+3

+ Genital Diseases

+ Genital Diseases, Male

From 25 to 45 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 3
Interventional
Study Start: July 2022
See protocol details

Summary

Principal SponsorShakeela Ishrat
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2022

Actual date on which the first participant was enrolled.

This clinical trial focuses on understanding whether the drug clomiphene citrate can improve sperm quality in men who have difficulty with fertility due to a condition called idiopathic oligoasthenozoospermia, which affects sperm count and movement. The study is important because it aims to find out if clomiphene citrate can offer a new way to help these men increase their chances of conception, addressing a significant challenge for couples trying to have children. Participants in the study will receive either clomiphene citrate or a placebo, which looks like the drug but contains no active ingredients. The study will monitor changes in sperm count and movement to see if clomiphene citrate makes a difference. It will also keep track of any side effects participants experience to assess the safety of the treatment. This approach ensures that any improvements in sperm parameters can be confidently attributed to clomiphene citrate.

Official TitleThe Effect of Clomiphene Citrate on Sperm Parameters in Infertile Men With Idiopathic Oligoasthenozoospermia
Principal SponsorShakeela Ishrat
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

From 25 to 45 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesGenital Diseases, MaleInfertilityInfertility, MaleMale Urogenital Diseases

Criteria

2 inclusion criteria required to participate
Infertile men

Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was >300 ng/dl)

10 exclusion criteria prevent from participating
Azoospermia

Body mass index <18 kg/m2 and >30 kg/m2

Any abnormality on genital examination and scrotal sonogram

History of genital diseases & genital surgery

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Participants will receive Tab Clomiphene citrate 50 mg orally once daily or 12 weeks

Group II

Placebo
Participants will receive Clomiphene citrate placebo tablet matching Clomiphene citrate orally once daily for 12 weeks

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Bangabandhu Sheikh Mujib Medical University

Dhaka, BangladeshOpen Bangabandhu Sheikh Mujib Medical University in Google Maps
CompletedOne Study Center