Internal Mammary Lymph Nodes Irradiation for High-risk Breast Cancer

This study focuses on women with high-risk breast cancer who have already received a type of cancer treatment called neoadjuvant chemotherapy. These women have cancer that has spread to certain lymph nodes. The study investigates whether adding a specific type of radiation treatment, called internal mammary lymph node irradiation (IMNI), to the usual radiation therapy can be beneficial. The goal is to see if IMNI improves outcomes for these patients by potentially reducing the chance of cancer returning or spreading. Participants in this study receive regional nodal irradiation alongside radiation to the breast or chest wall. They are randomly assigned to two groups: one receives the additional IMNI radiation, while the other does not. By comparing the results of the two groups, researchers aim to assess the impact of IMNI on the progression of the disease. The study does not specify immediate risks or benefits of IMNI, but the goal is to understand whether its inclusion provides significant help in treating high-risk breast cancer.