Completed

Resistant Dextrin's Impact on Blood Glucose and Health in Singaporeans

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What is being tested

Control

+ Treatment

Other
Who is being recruted

Hyperinsulinism+2

+ Insulin Resistance

+ Metabolic Diseases

From 21 to 60 Years
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: August 2019
See protocol details

Summary

Principal SponsorSingapore Institute of Food and Biotechnology Innovation
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 14, 2019

Actual date on which the first participant was enrolled.

This study is focused on understanding how different types of carbohydrates, particularly dietary fiber like resistant dextrin, affect human health and blood sugar management. Dietary fiber is known for its role in reducing the risk of various health issues such as heart disease, diabetes, and obesity. However, many people do not consume enough fiber daily, especially in Singapore. The study aims to explore how resistant dextrin, a type of soluble fiber with prebiotic properties, can improve blood sugar levels, lower cholesterol, reduce inflammation, and help with weight loss. This research is particularly important as it seeks to provide evidence-based dietary recommendations for Asian populations, which are currently lacking. Participants in the study will consume resistant dextrin to observe its effects on health and weight management. The study will monitor various health indicators, such as blood glucose levels and cholesterol, to determine the benefits of resistant dextrin. Additionally, researchers will investigate whether this fiber can induce the production of short-chain fatty acids, which may promote fat burning and weight loss. By examining these outcomes, the study hopes to provide clearer insights into how resistant dextrin can be used as a dietary supplement to improve overall health.

Official TitleThe Acute-postprandial and Long-term Effects of Different Types of Carbohydrate on Human Health and Blood Glucose Management
NCT06554002
Principal SponsorSingapore Institute of Food and Biotechnology Innovation
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

98 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 21 to 60 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HyperinsulinismInsulin ResistanceMetabolic DiseasesNutritional and Metabolic DiseasesGlucose Metabolism Disorders

Criteria

Inclusion Criteria: * 21 to 60 years old * Group A: 21 - 25 kg/m2, with first degree family history of type 2 diabetes, or Group B: 23 - 30 kg/m2, with waist circumference \>85 cm for males and \>82 cm for females Exclusion Criteria: * • Consume fibre supplements or any other supplements that is likely to interfere with study outcomes * Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug * Smoking * Have any metabolic diseases (e.g. diabetes, hypertension) * Have medical conditions and/or taking medications known to affect glycaemia (e.g. glucocorticoids, thyroid hormones, thiazide diuretics) * Have glucose-6-phosphate dehydrogenase (G6PD) deficiency * Have any severe food allergy (e.g. anaphylaxis to peanuts), or any other known food allergy/intolerance * Have active Tuberculosis (TB) or currently receiving treatment for TB * Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) * A team member of the study or their immediate family members (i.e. spouse, parent, child, or sibling, whether biological or legally adopted) * Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC. * Intentionally restricting food intake * Have poor veins impeding venous access * Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws * Have claustrophobia

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Flavoured beverage powder with 3g glucose, twice a day

Group II

Experimental
Flavoured beverage powder with 20g resistant dextrin, twice a day

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Clinical Nutrition Research Centre (CNRC)

Singapore, SingaporeOpen Clinical Nutrition Research Centre (CNRC) in Google Maps
CompletedOne Study Center