Resistant Dextrin's Impact on Blood Glucose and Health in Singaporeans
Control
+ Treatment
Hyperinsulinism+2
+ Insulin Resistance
+ Metabolic Diseases
Other Study
Summary
Study start date: August 14, 2019
Actual date on which the first participant was enrolled.This study is focused on understanding how different types of carbohydrates, particularly dietary fiber like resistant dextrin, affect human health and blood sugar management. Dietary fiber is known for its role in reducing the risk of various health issues such as heart disease, diabetes, and obesity. However, many people do not consume enough fiber daily, especially in Singapore. The study aims to explore how resistant dextrin, a type of soluble fiber with prebiotic properties, can improve blood sugar levels, lower cholesterol, reduce inflammation, and help with weight loss. This research is particularly important as it seeks to provide evidence-based dietary recommendations for Asian populations, which are currently lacking. Participants in the study will consume resistant dextrin to observe its effects on health and weight management. The study will monitor various health indicators, such as blood glucose levels and cholesterol, to determine the benefits of resistant dextrin. Additionally, researchers will investigate whether this fiber can induce the production of short-chain fatty acids, which may promote fat burning and weight loss. By examining these outcomes, the study hopes to provide clearer insights into how resistant dextrin can be used as a dietary supplement to improve overall health.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.98 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 21 to 60 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * 21 to 60 years old * Group A: 21 - 25 kg/m2, with first degree family history of type 2 diabetes, or Group B: 23 - 30 kg/m2, with waist circumference \>85 cm for males and \>82 cm for females Exclusion Criteria: * • Consume fibre supplements or any other supplements that is likely to interfere with study outcomes * Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug * Smoking * Have any metabolic diseases (e.g. diabetes, hypertension) * Have medical conditions and/or taking medications known to affect glycaemia (e.g. glucocorticoids, thyroid hormones, thiazide diuretics) * Have glucose-6-phosphate dehydrogenase (G6PD) deficiency * Have any severe food allergy (e.g. anaphylaxis to peanuts), or any other known food allergy/intolerance * Have active Tuberculosis (TB) or currently receiving treatment for TB * Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) * A team member of the study or their immediate family members (i.e. spouse, parent, child, or sibling, whether biological or legally adopted) * Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC. * Intentionally restricting food intake * Have poor veins impeding venous access * Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws * Have claustrophobia
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Clinical Nutrition Research Centre (CNRC)
Singapore, SingaporeOpen Clinical Nutrition Research Centre (CNRC) in Google Maps