TrichlosilTopical Trichloroacetic Acid for HPV-Related Low-Grade Cervical Lesions

This clinical trial is exploring the effectiveness of using a topical solution called 85% Trichloroacetic Acid (TCA) for women aged 18 to 65 who have been diagnosed with low-grade squamous intraepithelial lesions (LSIL) caused by human papillomavirus (HPV). The study is focused on women who have been referred to a colposcopy clinic due to abnormalities found in cervical screening tests, such as ASC-US, LSIL, or persistent high-risk HPV infections. The aim is to see if applying TCA can clear the HPV infection and lead to complete remission of these cervical lesions, potentially offering a new treatment option to improve patient outcomes. Participants in the study are randomly divided into two groups. One group receives the TCA treatment applied directly to the affected cervical areas using a cotton-tipped applicator, while the other group receives a placebo treatment using 3% acetic acid applied in the same way. After the treatment, participants are monitored for any discomfort and advised on post-treatment care. They are followed up after two weeks and again after three months to check for healing and any changes in their condition. The main goal is to see if there is complete remission of the lesions and whether there is clearance of the specific HPV type involved. The study will measure these outcomes through examinations and tests, aiming to provide evidence on the efficacy of TCA in treating LSIL.