Suspended

Pulp capDirect Pulp Capping vs. Partial Pulpotomy for Carious Pulp Exposure in Mature Teeth

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Study Aim

The study compares the effectiveness of direct pulp capping and partial pulpotomy in resolving symptoms in adults with carious pulp exposure in mature teeth.

What is being tested

Direct pulp capping and partial pulpotomy

Procedure
Who is being recruted

Dental Pulp Diseases+5

+ Stomatognathic Diseases

+ Neurologic Manifestations

From 12 to 60 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: March 2023
See protocol details

Summary

Principal SponsorKing Abdullah University Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 25, 2023

Actual date on which the first participant was enrolled.

This clinical trial is focused on finding the best way to treat teeth with deep cavities that expose the pulp, which is the innermost part of a tooth containing nerves and blood vessels. The study aims to compare two treatment methods: direct pulp capping and partial pulpotomy, using a material called Biodentine. It targets mature teeth with symptoms that suggest the pulp inflammation can be reversed, a condition known as reversible pulpitis. The research is significant because it seeks to improve the success rates of these treatments, which can help preserve natural teeth and reduce the need for more invasive procedures like root canals. Participants in the study will have one of two procedures: direct pulp capping, where a protective layer is placed over the exposed pulp, or partial pulpotomy, which involves removing a small portion of the pulp before sealing it. The study will monitor the pain levels of participants at 48 hours and 7 days after the procedure using a pain scale. Additionally, blood from the pulp will be tested for certain substances (MMP9 levels) that might affect the treatment's success. Patients' treated teeth will be checked both clinically and with X-rays at 6 and 12 months, and then annually, to determine the long-term effectiveness of the treatments.

Official TitleOutcome of Direct Pulp Capping Compared to Partial Pulpotomy in the Management of Carious Pulp Exposures in Mature Teeth: A Randomized Clinical Trial
NCT06495242
Principal SponsorKing Abdullah University Hospital
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

120 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 12 to 60 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dental Pulp DiseasesStomatognathic DiseasesNeurologic ManifestationsPainPulpitisSigns and SymptomsPathological Conditions, Signs and SymptomsTooth Diseases

Criteria

Inclusion Criteria: * Non -contributory medical history (ASA 1) * Molar tooth with extremely deep caries extending\>2/3 of dentin or exposing the pulp on the periapical radiograph * The tooth should give positive response to cold testing * Clinical diagnosis of reversible pulpitis with mild to moderate symptoms * The tooth is restorable, probing pocket depth and mobility are within normal limits * No signs of pulpal necrosis including sinus tract or swelling * No radiographic evidence of periapical changes indicative of apical periodontitis Exclusion Criteria: Immature teeth * Nonvital teeth * Irreversible pulpitis and periapical periodontitis, i.e spontaneous and lingering pain. * Inability to achieve hemostasis after 6 minutes of application of 5% NaOCl moist pellet * No pulp exposure after nonselective caries removal

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
After caries excavation and pulp exposure, the cavity is disinfected . the capping material is applied and the tooth is restored.

Group II

Active Comparator
After caries excavation and pulp exposure, 2-3 mm of the exposed pulp are cut . The capping material is applied and the tooth is restored.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Faculty of Dentistry, Jordan University of Science and Technology

Irbid, JordanOpen Faculty of Dentistry, Jordan University of Science and Technology in Google Maps
SuspendedOne Study Center