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Nano-hydroxyapatite Toothpaste for Dentin Hypersensitivity Relief

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Study Aim

This study aims to evaluate the effectiveness of nano-hydroxyapatite toothpaste in reducing pain intensity for adults experiencing dentin hypersensitivity.

What is being tested

Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste

+ Eggshell derived Nano-hydroxyapatite (n-HAp) without a Fluoride containing toothpaste

Drug
Who is being recruted

Dentin Sensitivity

+ Stomatognathic Diseases

+ Tooth Diseases

From 18 to 60 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1
Interventional
Study Start: July 2024
See protocol details

Summary

Principal SponsorCairo University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2024

Actual date on which the first participant was enrolled.

This study is exploring a new toothpaste containing nano-hydroxyapatite (n-HAp) to help adults with sensitive teeth, a condition known as dentin hypersensitivity. The n-HAp particles are incredibly small and similar to the natural minerals found in teeth. They are designed to penetrate the tiny channels in teeth that cause sensitivity, potentially blocking them and reducing discomfort. The study aims to test how effective this toothpaste is, which could offer a new way to relieve the pain often experienced by those with sensitive teeth. Participants in the study use the toothpaste containing n-HAp as directed. Researchers observe how well the toothpaste works in reducing dental sensitivity by examining changes in discomfort levels. The particles in the toothpaste aim to act like fillers, entering the channels in the teeth and stopping the movement of fluid, which is what typically causes the sensitivity. This study does not list specific outcomes or risks, but it is a Phase 1 trial, indicating early-stage testing of the product's safety and potential benefits.

Official TitleEfficacy of Nano-hydroxyapatite Containing Tooth Paste on Dentin Hypersensitivity of Adult Patient
NCT06493500
Principal SponsorCairo University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

39 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 60 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dentin SensitivityStomatognathic DiseasesTooth Diseases

Criteria

6 inclusion criteria required to participate
Adult Patients Aged 18-60

Males or females.

Good oral hygiene

Absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing).

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7 exclusion criteria prevent from participating
Patients with known allergic or adverse reaction to the tested materials.

Systematic disease that may affect participation.

Xerostomic patients.

Patients with bad oral hygiene

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
patients would be instructed totreat their teeth for 5 min twice a day with the provided toothpaste.

Group II

Experimental
patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.

Group III

Experimental
patients would be instructed totreat their teeth for 5 min twice a day with the provided toothpaste.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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