Suvorexant on Brain Dopamine Receptors in Alcohol Use Disorder

This study aims to explore how a medication called suvorexant affects the brain and behavior of people with Alcohol Use Disorder (AUD) who are undergoing detoxification. The focus is on understanding how suvorexant impacts certain brain receptors related to dopamine, a chemical involved in pleasure and reward. The researchers believe that suvorexant might help improve sleep, reduce cravings for alcohol, and lessen negative moods. This research could potentially lead to better treatment options for those struggling with alcohol addiction by addressing issues like poor sleep and cravings, which are common challenges during recovery. Participants in this study will take suvorexant or a placebo for 3-4 weeks. The effects on their brain will be monitored using advanced imaging techniques, and changes in sleep patterns will be measured with sleep studies. Participants will also provide feedback on their sleep quality and alcohol cravings. The study will assess changes in brain chemistry, structure, and function, as well as cognitive performance. The potential risks involve typical side effects related to the suvorexant medication, but the benefits could include improved sleep and reduced cravings, which are crucial for successful detoxification and recovery.