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REPLACEPatient Perception and Oral Function of Implant-supported Restorations for Posterior Teeth

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Study Aim

This study aims to evaluate the patient's perception and oral function of implant-supported restorations for posterior teeth, focusing on changes in marginal bone loss, oral function, and oral health related quality of life.

What is being tested

Splinted

Other
Who is being recruted

Bites and Stings+1

+ Poisoning

+ Wounds and Injuries

Over 30 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: March 2024
See protocol details

Summary

Principal SponsorUniversity of Copenhagen
Study ContactChahak Seth-Johansen, DDSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 1, 2024

Actual date on which the first participant was enrolled.

This clinical trial investigates how different dental treatments affect chewing ability and overall oral health quality of life for people missing back teeth. The study aims to determine whether implant-supported crowns, removable dental prostheses, or no treatment affect patients' perceptions of their chewing function and oral health differently. It also compares two digital methods for assessing how teeth come together and whether crowns that are joined together (splinted) or used individually (non-splinted) lead to different biological and technical outcomes. The study targets adults who are in good health, have missing back teeth, and are considering implant-supported crowns to replace these teeth. This research is significant as it may help improve dental care by identifying the most effective and patient-friendly treatment options for those with missing teeth. Participants will undergo various tests and procedures during the study. Initially, they will be screened with X-rays and other assessments to ensure they meet the study criteria and do not have conditions that could interfere with treatment. Participants will receive implant-supported crowns and undergo tests to measure their bite force, chewing time, and muscle activity during chewing. They will also complete questionnaires about their oral health and ability to chew different foods. Some participants will have their crowns joined together, while others will have them as individual units to assess the differences. Digital scans and traditional methods will be used to record how teeth meet during biting. The study will follow participants over time to assess outcomes like changes in bone levels around the implants and any complications with the crowns. This will help determine the most effective treatment approach for improving oral function and quality of life.

Official TitlePatient Perception and Oral Function of Implant-supported Restorations Replacing Posterior Teeth
Principal SponsorUniversity of Copenhagen
Study ContactChahak Seth-Johansen, DDSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

20 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 30 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bites and StingsPoisoningWounds and InjuriesChemically-Induced Disorders

Criteria

1 inclusion criteria required to participate
Partially edentulous subjects with missing posterior teeth (Kennedy class I or class II) in the upper or lower jaw, in need for fixed implant-supported crowns to replace the missing teeth are offered to be enrolled if they fulfill the following inclusion criteria. The participants must be in good health and with no contraindications for undergoing dento-alveolar surgery.

12 exclusion criteria prevent from participating
Untreated or active, progressive periodontitis

Intake of (high dose) antiresorptive medicine or earlier medication related osteonecrosis of the jaw

Therapeutic radiation to the head and neck

Uncontrolled diabetes or systemic corticosteroids

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Group II

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Faculty of Health and Medical Sciences

Copenhagen, DenmarkOpen Faculty of Health and Medical Sciences in Google Maps
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One Study Center
REPLACE | Patient Perception and Oral Function of Implant-supported Restorations for Posterior Teeth | PatLynk