Completed

ZASUSLocally Adapted Stroke Unit for Improved Outcomes in Lusaka, Zambia

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Study Aim

This study aims to improve stroke outcomes by evaluating the proportion of clinical practice guidelines followed during your inpatient admission in a locally adapted stroke unit in Lusaka, Zambia.

What is being tested

Stroke Unit

Other
Who is being recruted

Brain Diseases+4

+ Cardiovascular Diseases

+ Central Nervous System Diseases

Over 18 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Services Research Study

Interventional
Study Start: October 2024
See protocol details

Summary

Principal SponsorJohns Hopkins University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 25, 2024

Actual date on which the first participant was enrolled.

This study aims to evaluate a new system of stroke care at the University Teaching Hospital in Lusaka, Zambia, to see if it can improve outcomes for people who have had a stroke. Stroke is a major health issue in Zambia and worldwide, especially in low- and middle-income countries where most stroke-related deaths and disabilities occur. The new system is designed to be locally relevant by considering unique risk factors and the resources available in Zambia. This research is important because it could lead to better stroke care and reduce deaths and disabilities in Zambia and potentially in other similar settings. Participants in this study will be adults who have experienced a stroke and are admitted to the hospital in Lusaka. The study will compare the results of stroke care under the new guidelines with past care practices to see if there is an improvement in the quality of care and patient outcomes. Researchers will look at how well the hospital follows the new stroke care guidelines and measure in-hospital and post-discharge mortality rates. The study does not involve any new drugs or acute stroke treatments but focuses on improving the organization and delivery of stroke care. If successful, the findings could help improve stroke care systems in other similar regions.

Official TitleEvaluation of a Locally Adapted Stroke Unit to Improve Outcomes in Lusaka, Zambia
NCT06457048
Principal SponsorJohns Hopkins University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

300 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Services Research Study

These studies look at how healthcare is delivered, managed, and organized. They aim to improve care quality, patient experience, and access to treatment.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesCardiovascular DiseasesCentral Nervous System DiseasesCerebrovascular DisordersNervous System DiseasesVascular DiseasesStroke

Criteria

3 inclusion criteria required to participate
Clinically suspected diagnosis of stroke by treating neurologist or imaging-confirmed diagnosis of stroke

Symptom onset (last known normal) within 7 days of presentation to the University Teaching Hospital in Lusaka, Zambia

Inpatient admission to the University Teaching Hospital in Lusaka, Zambia

1 exclusion criteria prevent from participating
Refusal to give informed consent

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
All participants in this study will be adults with stroke cared for in the recently implemented stroke unit at the University Teaching Hospital in Lusaka, Zambia. Of note, all adults with stroke admitted to the University Teaching Hospital during the study period will be cared for in the stroke unit regardless of participation participation in this study. However, only those who consent to study participation will have data collected.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University Teaching Hospital

Lusaka, ZambiaOpen University Teaching Hospital in Google Maps
CompletedOne Study Center