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Effect of Postural Change on Hemoglobin Level in Patients on the Intensive Care Unit

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What is being tested

Postural change from supine to sitting

+ Mobilization to a chair

Procedure
Who is being recruted

Anemia

+ Hematologic Diseases

+ Hemic and Lymphatic Diseases

Over 18 Years
+23 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Diagnostic Study

Interventional
Study Start: June 2024
See protocol details

Summary

Principal SponsorDeventer Ziekenhuis
Study ContactAlfred L van Steveninck, M.D., Ph.D.More contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 17, 2024

Actual date on which the first participant was enrolled.

This study focuses on understanding how changes in body position affect hemoglobin levels in patients admitted to the intensive care unit (ICU). Hemoglobin is a crucial component of blood that carries oxygen throughout the body, and its levels are monitored to detect anemia. In ICU patients, who are often bedridden, changes in posture might cause the hemoglobin levels to fluctuate, leading to a condition called 'postural pseudoanemia.' This can result in unnecessary treatments like blood transfusions, which carry risks of adverse reactions. By studying this phenomenon in ICU patients, the research aims to prevent unnecessary interventions and improve patient care. In the study, ICU patients over the age of 18 will change their posture from lying down to sitting upright and then move to a chair. The researchers will measure the changes in hemoglobin levels during these movements. They will also look at other blood components like serum albumin, uric acid, CRP, and ESR to see if there's a correlation with hemoglobin changes. This process helps identify if the shifts in hemoglobin levels are significant and need medical attention. The main focus is to track the percentage change in hemoglobin to understand if posture changes lead to misleading low hemoglobin readings that could affect patient treatment decisions.

Official TitleEffect of Postural Change on Hemoglobin Level in Patients on the Intensive Care Unit
Principal SponsorDeventer Ziekenhuis
Study ContactAlfred L van Steveninck, M.D., Ph.D.More contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

24 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Diagnostic Study

Diagnostic studies focus on improving how we detect or confirm a disease. They test new tools or techniques that could provide faster or more accurate diagnoses.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AnemiaHematologic DiseasesHemic and Lymphatic Diseases

Criteria

6 inclusion criteria required to participate
Age over 18 years, of any gender and ethnic background

Admitted to the intensive care unit

Able to give informed consent

Patients with an arterial line as part of their treatment plan.

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17 exclusion criteria prevent from participating
Delirium or inability to give informed consent

Inability to understand written information in Dutch

Patients on artificial ventilation

Orotracheally intubated patients (spontaneous breathing through a tracheostomy cannula is allowed)

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Hemoglobin concentration after sitting in bed (passively) for \>30 min, and after mobilization to a chair for \>30 min

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Deventer Hospital

Deventer, NetherlandsOpen Deventer Hospital in Google Maps
Recruiting soonOne Study Center