Suspended

The Functional Importance of Powered Wrist Flexion for Transradial Prosthetic Users

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What is being tested

Clinically prescribed prosthesis

+ Experimental prosthesis - Wrist rotation + 1-DOF

+ Experimental prosthesis - Wrist rotation + Wrist flexion +1-DOF

Device
Who is being recruted

Amputation, Traumatic

+ Wounds and Injuries

From 18 to 70 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: April 2020
See protocol details

Summary

Principal SponsorShirley Ryan AbilityLab
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 20, 2020

Actual date on which the first participant was enrolled.

This study aims to explore the importance of powered wrist flexion in prosthetic devices for individuals with transradial amputations, which refers to amputations below the elbow. It focuses on understanding how new prosthetic technologies and control methods can improve the way users perform everyday tasks. Many current assessment methods only measure how quickly a task is completed, without considering the quality of movement or the specific movements involved. This research is significant because it seeks to fill this gap by evaluating the benefits of advanced prosthetic components, potentially leading to better designs that enhance the daily lives of prosthetic users. Participants in the study engage in tasks using a system called the Gaze and Movement Assessment (GaMA), which evaluates how well prosthetics work by analyzing movements in three dimensions, eye movements, and task performance. The tasks include moving a cup and a pasta box, simulating everyday actions that require reaching and handling objects at different heights. These tasks are divided into steps like reaching, grasping, transporting, and releasing the object, allowing researchers to study each movement in detail. The study measures how different prosthetic components affect these movements, with the aim of improving prosthetic designs to reduce the need for extra body adjustments. The study also gathers data to verify the GaMA system's effectiveness in assessing prosthetic use.

Official TitleThe Functional Importance of Powered Wrist Flexion for Transradial Prosthetic Users
NCT06420687
Principal SponsorShirley Ryan AbilityLab
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

45 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Amputation, TraumaticWounds and Injuries

Criteria

3 inclusion criteria required to participate
A unilateral upper limb amputation or absence below the elbow

Ability to use a myoelectric prosthesis

English Speaking

3 exclusion criteria prevent from participating
Significant new injury that would prevent use of a prosthesis: The ability to consistently wear a prosthesis and perform activities of daily living and specific performance tasks is necessary to evaluate the relative benefits of the interventions.

Cognitive impairment sufficient to adversely affect understanding of or compliance with study requirements, ability to communicate experiences, or ability to give informed consent: The ability to understand and comply with requirements of the study is essential in order for the study to generate useable, reliable data.

Significant other comorbidity: Any other medical issues or injuries that would preclude completion of the study, use of the prostheses, or that would otherwise prevent acquisition of useable data by researchers

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

5 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Individuals using their home prosthesis when available. Adhesive motion capture markers will be placed on both arms (upper arm, forearm, hand and finger tips), thoracic spine and sacrum. The participant will wear a headband with attached markers for eye tracking. The participant will pick up and move objects of different shapes to and from various heights.

Group II

Experimental
Individuals with transradial amputation fit with experimental prosthesis consisting of wrist rotation and one degree of freedom hand. Adhesive motion capture markers will be placed on both arms (upper arm, forearm, hand and finger tips), thoracic spine and sacrum. The participant will wear a headband with attached markers for eye tracking. The participant will pick up and move objects of different shapes to and from various heights.

Group III

Experimental
Individuals with transradial amputation fit with experimental prosthesis consisting of wrist rotation, wrist flexion and one degree of freedom hand. Adhesive motion capture markers will be placed on both arms (upper arm, forearm, hand and finger tips), thoracic spine and sacrum. The participant will wear a headband with attached markers for eye tracking. The participant will pick up and move objects of different shapes to and from various heights.

Group IV

Experimental
Individuals with transradial amputation fit with experimental prosthesis consisting of wrist rotation and multi degree freedom hand. Adhesive motion capture markers will be placed on both arms (upper arm, forearm, hand and finger tips), thoracic spine and sacrum. The participant will wear a headband with attached markers for eye tracking. The participant will pick up and move objects of different shapes to and from various heights.

Group 5

Experimental
Individuals with transradial amputation fit with experimental prosthesis consisting of wrist rotation, wrist flexion and multi degree freedom hand. Adhesive motion capture markers will be placed on both arms (upper arm, forearm, hand and finger tips), thoracic spine and sacrum. The participant will wear a headband with attached markers for eye tracking. The participant will pick up and move objects of different shapes to and from various heights.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Shirley Ryan AbilityLab

Chicago, United StatesOpen Shirley Ryan AbilityLab in Google Maps
SuspendedOne Study Center
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