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The Effect of Reducing Ejaculation Abstinence Time on Assisted Reproductive Technology Outcomes: a Prospective Randomized Controlled Study

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What is being tested

Shorten abstinence time

Behavioral
Who is being recruted

From 20 to 45 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: May 2024
See protocol details

Summary

Principal SponsorThe First Hospital of Jilin University
Study ContactYueying Zhu, MasterMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2024

Actual date on which the first participant was enrolled.

This study is focusing on understanding if changing the time men abstain from ejaculation before a fertility treatment can make the process more successful. The research specifically looks at assisted reproductive technology, which includes procedures like in vitro fertilization (IVF). The usual recommendation for men is to abstain from ejaculation for 2-7 days, but this study is testing if a shorter period of just 48 hours could be more beneficial. This research is important as it could provide clearer guidelines for men undergoing fertility treatments, potentially improving the chances of conception for couples facing fertility issues. Participants in this study are divided into two groups. One group will abstain from ejaculation for 48 hours before the egg retrieval process, while the other group will follow the traditional 4-7 days of abstinence. The study will follow the results of their IVF treatments to compare the outcomes between the two groups. The aim is to see if the shorter abstinence period results in better fertility treatment outcomes. This involves carefully tracking the success of the IVF procedures to determine which method is more effective.

Official TitleThe Effect of Reducing Ejaculation Abstinence Time on Assisted Reproductive Technology Outcomes: a Prospective Randomized Controlled Study
NCT06410417
Principal SponsorThe First Hospital of Jilin University
Study ContactYueying Zhu, MasterMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 20 to 45 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
The couple is between 20 and 45 years old, and the woman's body mass index is greater than 18.5 and less than 30kg/m2.

Meet the indications of assisted reproductive technology, agree to use assisted reproductive technology to assist pregnancy and have entered the process.

The male has normal ejaculation function and plans to provide a semen sample by masturbation method on the day of egg retrieval.

5 exclusion criteria prevent from participating
Couples with serious infections and major physical diseases, such as HIV.

The use of testicular sperm for intracytoplasmic sperm injection, such as the azoospermia.

The use of frozen sperm for assisted reproductive technology.

Endometriosis, repeated implantation failure, etc.

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
abstinence time is less than 48 hours

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

the first hospital of Jilin University

Changchun, ChinaOpen the first hospital of Jilin University in Google Maps
Recruiting
One Study Center