Completed

The Effect of Vitamin C-enriched Collagen Combined With Resistance Training on Muscle-tendon Unit Properties in Middle-aged Men and Women

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What is being tested

Resistance training with collagen supplementation

Dietary Supplement
Who is being recruted

From 35 to 59 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: July 2021
See protocol details

Summary

Principal SponsorLiverpool John Moores University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2021

Actual date on which the first participant was enrolled.

This study focuses on understanding how a vitamin C-enriched collagen drink, when combined with resistance training, impacts the muscles and tendons of healthy, active middle-aged men and women. The research aims to see if this combination could improve tendon size, stiffness, and overall strength more effectively than exercise alone. This is particularly important for middle-aged individuals who want to maintain or enhance their physical performance and reduce the risk of injuries. By exploring this combination, the study hopes to offer new strategies for improving tendon health and athletic performance in this age group. Participants in the study will drink a special beverage containing hydrolyzed collagen and vitamin C or a similar drink with maltodextrin and vitamin C. They will then engage in high-intensity resistance training for their lower body two to three times a week over the course of 8 to 12 weeks. The study will observe changes in the tendons, such as size and stiffness, to determine the effectiveness of the collagen supplement combined with resistance training. There are two groups in the study, one consisting of men and the other of women, to see if there are any differences in outcomes between genders.

Official TitleThe Effect of Vitamin C-enriched Collagen Combined With Resistance Training on Muscle-tendon Unit Properties in Middle-aged Men and Women
NCT06402890
Principal SponsorLiverpool John Moores University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

42 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 35 to 59 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
Recreationally active or competing in Masters sport
No history of patellar tendon injuries in the past 6 months
No history of lower limb musculoskeletal injuries in the past 6 months
Non-smokers (including e-cigarettes)
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5 exclusion criteria prevent from participating
Age < 35 years or > 59 years
Being vegan or vegetarian (due to the mammalian source of collagen)
Injury history incompatible with lower body resistance training
Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Middle-aged, trained males completed 12-weeks of a supervised, progressive resistance training programme while consuming 30 g of hydrolyzed collagen or a calorie matched placebo beverage.

Group II

Experimental
Middle-aged, trained females completed 8-weeks of a supervised, progressive resistance training programme while consuming 30 g of hydrolyzed collagen or a calorie matched placebo beverage

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Dr Rob Erskine

Liverpool, United KingdomOpen Dr Rob Erskine in Google Maps
CompletedOne Study Center