The Effect of Low Dose Pregabalin and Etoricoxib Combination on Pain in Comparison to Etoricoxib Alone in Patients Suffering From Chronic Low Back Pain

This clinical study is exploring how effective a combination of two medications, Pregabalin and Etoricoxib, is in reducing pain for people suffering from chronic low back pain. Chronic low back pain is a persistent and often debilitating condition affecting a significant portion of the population, especially those over the age of 50. The study aims to find better treatment methods as many current options do not effectively address all types of pain associated with this condition, particularly neuropathic pain. By utilizing Pregabalin, which targets nerve pain, alongside Etoricoxib, the study seeks to improve pain management and reduce disability for those affected. Participants in the study are divided into two groups. Initially, all participants receive Etoricoxib and a placebo for four weeks. After this period, one group continues with only Etoricoxib, while the other group begins taking Pregabalin in addition to Etoricoxib for another four weeks. The effectiveness of the treatment is evaluated by checking pain levels using a numeric scale and assessing how much the pain impacts daily activities. The study also measures liver enzyme levels to monitor any potential side effects. Additionally, the participants' overall impression of their improvement is recorded. These results help determine whether the combination of these medications provides a significant improvement in managing chronic low back pain compared to Etoricoxib alone.