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The Comparative Results of Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist Ovarian Stimulation Methods on IVF Outcomes

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What is being tested

Progestin

+ GnRH antagonist

Drug
Who is being recruted

Urogenital Diseases

+ Genital Diseases

+ Infertility

From 18 to 45 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: August 2024
See protocol details

Summary

Principal SponsorNesta Clinic
Study ContactZuhal Yucel, B.N.
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2024

Actual date on which the first participant was enrolled.

This clinical trial aims to compare two different methods of ovarian stimulation used in in vitro fertilization (IVF): Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist. The study focuses on women undergoing IVF treatment to see which method results in better embryologic outcomes. Understanding which approach is more effective could help improve the success rates of IVF treatments, providing better options for those trying to conceive. Participants in the study will be assigned to one of the two stimulation methods. For those in the artificially prepared cycle group, the medication Estradiol Hemihydrate will be taken orally starting on the second day of the menstrual cycle. After two weeks, doctors will measure the thickness of the uterine lining and progesterone levels to ensure the cycle can continue. For luteal support, Progesterone is administered both by injection and vaginally at specific times during the cycle. Embryo transfer takes place on the sixth day after starting progesterone treatment, with continued hormone support to aid pregnancy development up to eight weeks. This study does not specify risks or benefits, focusing on comparing the effectiveness of the two stimulation methods.

Official TitleThe Comparative Results of Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist Ovarian Stimulation Methods on IVF Outcomes
Principal SponsorNesta Clinic
Study ContactZuhal Yucel, B.N.
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

152 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 18 to 45 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesInfertility

Criteria

3 inclusion criteria required to participate
BMI > 18 kg/m2 ve <35 kg/m2

Couples that accept being included in the study

Couple accepting thawed embryo transfer

6 exclusion criteria prevent from participating
Known chromosomal abnormality in either member of the couple

Couples with unexplained infertility

BMI > 30 kg/m2

Mullerian malformations

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
In this patient group, progestin based protocol is going to be the main course of treatment.

Group II

Active Comparator
In this patient group, GnRH Antagonist treatment protocol is going to be the main course of treatment.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Nesta Clinic

Istanbul, Turkey (Türkiye)Open Nesta Clinic in Google Maps
Recruiting soonOne Study Center