The Comparative Results of Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist Ovarian Stimulation Methods on IVF Outcomes
Progestin
+ GnRH antagonist
Urogenital Diseases
+ Genital Diseases
+ Infertility
Treatment Study
Summary
Study start date: August 1, 2024
Actual date on which the first participant was enrolled.This clinical trial aims to compare two different methods of ovarian stimulation used in in vitro fertilization (IVF): Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist. The study focuses on women undergoing IVF treatment to see which method results in better embryologic outcomes. Understanding which approach is more effective could help improve the success rates of IVF treatments, providing better options for those trying to conceive. Participants in the study will be assigned to one of the two stimulation methods. For those in the artificially prepared cycle group, the medication Estradiol Hemihydrate will be taken orally starting on the second day of the menstrual cycle. After two weeks, doctors will measure the thickness of the uterine lining and progesterone levels to ensure the cycle can continue. For luteal support, Progesterone is administered both by injection and vaginally at specific times during the cycle. Embryo transfer takes place on the sixth day after starting progesterone treatment, with continued hormone support to aid pregnancy development up to eight weeks. This study does not specify risks or benefits, focusing on comparing the effectiveness of the two stimulation methods.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.152 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Female
Biological sex of participants that are eligible to enroll.From 18 to 45 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location