Clinical Evaluation of Biomimetic Self -Assembling Peptide (p11-4) in The Remineralization of Early Enamel Caries in Permanent Teeth

This study focuses on finding effective ways to repair early tooth decay in children, specifically targeting the outer layer of permanent teeth known as enamel. The research compares two treatments: one group of children will receive a new treatment using a special peptide called P11-4 combined with fluoride varnish, while another group will receive just the fluoride varnish. This study is important as it could lead to better ways to strengthen teeth and prevent cavities in children, which is crucial for maintaining healthy teeth into adulthood. Children participating in the study will undergo a thorough dental examination to record their dental health. Each child's teeth will be cleaned before the treatment is applied. The study group will receive the P11-4 peptide treatment, which involves applying the substance to the teeth and allowing it to dry, while the control group will receive a fluoride varnish applied with a brush. The effectiveness of these treatments will be assessed using two methods: a scoring system to observe visible changes and a laser device to measure mineral changes in the teeth over a period of 1, 3, and 6 months. Participants will be instructed not to eat or drink for 30 minutes after the treatment, and they will maintain oral hygiene using a soft toothbrush and fluoridated toothpaste.