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Modified Olfactory Training for Patients With Olfactory Disfunction:A Randomized Clinical Trial

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What is being tested

Modified olfactory training device

Device
Who is being recruted

Olfaction Disorders+3

+ Nervous System Diseases

+ Neurologic Manifestations

From 18 to 80 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2023
See protocol details

Summary

Principal SponsorPeking University Third Hospital
Study ContactDawei Wu, MD, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2023

Actual date on which the first participant was enrolled.

This study focuses on improving a therapy known as olfactory training, which helps people with a reduced sense of smell. The standard method involves patients repeatedly sniffing various odors to enhance their olfactory abilities. However, this approach often faces issues such as inconsistent methods and difficulties for patients to stick with the program. To address these challenges, a new device has been developed that uses pressure from breathing out, offers a two-way airflow, and includes features like voice prompts and automatic counting. This study is significant because it aims to provide a more effective and user-friendly method to help those struggling with smell disorders, potentially leading to better patient outcomes and adherence. The study plans to involve 72 participants, who will be divided into two groups. One group will use the traditional olfactory training methods, while the other will try out the new device. Participants will engage in regular sessions using their assigned method, and researchers will compare the results between the two groups to evaluate the effectiveness of the new device. The study does not specify risks but focuses on improving how well patients can follow the olfactory training and the potential improvements in their sense of smell.

Official TitleModified Olfactory Training for Patients With Olfactory Disfunction:A Randomized Clinical Trial
Principal SponsorPeking University Third Hospital
Study ContactDawei Wu, MD, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

72 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 80 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Olfaction DisordersNervous System DiseasesNeurologic ManifestationsSensation DisordersSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

4 inclusion criteria required to participate
Patients diagnosed with olfactory disorder when TDI score was less than 30.75.

Patients would perform Sniffin' Sticks examination.

Voluntarily sign the informed consent form

Able to undergo olfactory training and participate in follow-up visits

7 exclusion criteria prevent from participating
Smoking

Combined with chronic diseases, such as hypertension, diabetes, bronchopneumonia, chronic obstructive pulmonary disease, etc.

Those who have taken oral glucocorticoids, antibiotics, anti-leukotrienes, and antihistamines within four weeks will be excluded.

Patients who cannot tolerate olfactory function testing and treatment

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Group II

Active Comparator

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Dawei Wu

Beijing, ChinaOpen Dawei Wu in Google Maps
Recruiting
One Study Center