AGEDDXAGED Diagnostics Epigenetic Modifications of Liver Disease Assessment

This study focuses on improving the diagnosis of liver diseases, specifically targeting conditions like steatosis and non-alcoholic steatohepatitis (NASH). Researchers aim to identify specific biomarkers that can help distinguish between these conditions, which include varying levels of fibrosis in the liver. By looking at both liver tissue and blood plasma from patients, the study seeks to find reliable markers that reflect liver health and disease progression. This is important because better diagnostic tools can lead to more accurate and earlier detection of liver diseases, potentially improving treatment outcomes for affected individuals. Participants in the study will undergo procedures to collect liver tissue and blood plasma samples. These samples will then be analyzed using a technique called whole genome bisulfite sequencing to identify potential biomarkers. The study will further evaluate the identified biomarkers using targeted sequencing and PCR methods. Researchers will assess the performance of these biomarkers based on their accuracy in detecting liver conditions. The study aims to ensure that the markers are sensitive and specific, meaning they can accurately identify the presence of liver disease without giving false results. This research could lead to the development of a simple blood test to diagnose liver diseases more effectively.