Completed

The Effects of Cannabidiol (CBD) Cream on Delayed Onset Muscle Soreness (DOMS and Performance After Exercise

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What is being tested

Cannabidiol cream

+ Placebo cream

Other
Who is being recruted

Behavior+9

+ Motor Activity

+ Muscular Diseases

From 18 to 45 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Placebo-Controlled
Interventional
Study Start: August 2022
See protocol details

Summary

Principal SponsorJoseph Pastina
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 23, 2022

Actual date on which the first participant was enrolled.

This study investigates the effects of Cannabidiol (CBD) cream on muscle recovery after exercise, specifically targeting delayed onset muscle soreness (DOMS) and performance in the lower body muscles like the quadriceps and hamstrings. Participants are people from the Lexington area who are experiencing soreness after exercising. The study aims to find out if applying CBD cream can help reduce muscle soreness and improve recovery, potentially making it a useful treatment for athletes or anyone dealing with muscle pain after workouts. Participants are divided into three groups. One group applies CBD cream, another uses a placebo cream that looks and feels the same, and the last group does not use any cream. The study is double-blind, meaning neither the participants nor the researchers know who is using which cream, to ensure unbiased results. Over the course of five sessions in about 7 to 11 days, participants undergo various tests and procedures, including muscle strength tests and questionnaires about soreness. The study measures changes in muscle soreness and performance to see if the CBD cream has a noticeable impact compared to the placebo or no treatment.

Official TitleThe Effects of Cannabidiol (CBD) Cream on Delayed Onset Muscle Soreness (DOMS and Performance After Exercise
NCT06320327
Principal SponsorJoseph Pastina
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 45 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorMotor ActivityMuscular DiseasesMusculoskeletal DiseasesNervous System DiseasesNeurologic ManifestationsNeuromuscular DiseasesPainSigns and SymptomsPathological Conditions, Signs and SymptomsMusculoskeletal PainMyalgia

Criteria

4 inclusion criteria required to participate
Physically healthy
Age 18-45
Available for 5 sessions over the span of 2 weeks
Untrained (have not been participating in a structured resistance training routine for the past 2 months that includes 2 days of lower body resistance training per week)
3 exclusion criteria prevent from participating
Have not suffered a lower body injury in the previous 3 months
Be allergic to any ingredients within the CBD or placebo creams (ingredients listed in informed consent form)
Be pregnant

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
This group will apply the CBD cream in accordance with the manufacturer's recommendations at designated time points throughout the study.

Group II

Placebo
This group will apply a placebo moisturizer cream that will match the scent, volume, and viscosity of the CBD cream.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Seaton Center Building

Lexington, United StatesOpen Seaton Center Building in Google Maps
Suspended

Multidisciplinary Science Building

Lexington, United States
Completed2 Study Centers