Completed

ENDO-DCIEvaluation of D-Chiro-Inositol Treatment in Women With Endometriosis

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What is being tested

D-Chiro-Inositol

+ Placebo

Dietary SupplementOther
Who is being recruted

Urogenital Diseases+3

+ Genital Diseases

+ Endometriosis

From 18 to 40 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: April 2024
See protocol details

Summary

Principal SponsorUniversity of Palermo
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 15, 2024

Actual date on which the first participant was enrolled.

This clinical trial is focused on finding a new way to help women with endometriosis, a condition where tissue similar to the lining inside the uterus grows outside of it. Currently, the main treatment involves surgery to remove the lesions caused by endometriosis. However, these lesions can come back, often due to high levels of estrogen, a hormone in the body. While medications that balance estrogen levels exist, they can act as contraceptives and have side effects that many women find undesirable. This study aims to explore the potential of D-Chiro-Inositol, a naturally occurring compound in the body, as a supplement to reduce estrogen levels and prevent the return of endometriosis symptoms, while still allowing women to maintain their fertility. Participants in the study will take D-Chiro-Inositol as a dietary supplement. The goal is to observe if this supplement can effectively lower estrogen levels in the body, which might help reduce the recurrence of endometriosis and ease its symptoms. By focusing on a natural molecule like D-Chiro-Inositol, the study seeks to provide an alternative treatment option that is well tolerated and does not interfere with a woman's ability to become pregnant. The trial will monitor changes in estrogen levels and any improvements in endometriosis symptoms to evaluate the effectiveness of this approach.

Official TitleEvaluation of D-Chiro-Inositol Treatment in Women With Endometriosis
NCT06314126
Principal SponsorUniversity of Palermo
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

64 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesEndometriosisFemale Urogenital Diseases and Pregnancy ComplicationsGenital Diseases, FemaleFemale Urogenital Diseases

Criteria

1 inclusion criteria required to participate
Women affected by endometriosis (regardless of the stage)

5 exclusion criteria prevent from participating
Treatment with hormones in the previous three months or during the study

Treatment with Inositol and/or other insulin-sensitizers in the previous three months

Obesity

Diabetes

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Patients will receive oral D-Chiro-Inositol.

Group II

Placebo
Patients will receive oral placebo.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

"Paolo Giaccone" Hospital

Palermo, ItalyOpen "Paolo Giaccone" Hospital in Google Maps
CompletedOne Study Center