ANCHIALEApplication of Nanoparticles for Cyclic Hyperthermia In Adjuvant Therapy of gLioblastoma Multiforme (ANCHIALE)

This study focuses on improving treatment outcomes for patients with recurrent glioblastoma multiforme, a highly aggressive brain tumor. Current treatments, including surgery, radiotherapy, and chemotherapy, have limited success in extending the survival of patients. Researchers are exploring the use of a new therapy called NanoTherm, which involves the use of nanoparticles to generate heat and potentially enhance the effectiveness of existing treatments. By targeting the tumor area with heat, this method aims to destroy cancer cells more effectively and improve patients' survival rates and quality of life. Participants in the study will undergo surgery to remove as much of the tumor as possible. After that, a special solution containing nanoparticles will be applied to the remaining tumor site. These nanoparticles are then activated by a magnetic field to produce heat, a process done cyclically over a series of days to damage the cancer cells. Throughout the study, participants will have regular check-ups, including CT scans and assessments of their neurological health, to evaluate the treatment's impact on their condition. The study will last for two years, and the results from the NanoTherm treatment will be compared to the outcomes of standard neurosurgical treatments to determine its effectiveness and safety.