Suspended

Point of Care Test of LTA Level in Tear Fluid, Measured With a POCT Test, in DE Patients Following IPL Treatment

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What is being tested

M22

+ sham M22

Device
Who is being recruted

Eye Diseases

+ Lacrimal Apparatus Diseases

+ Dry Eye Syndromes

From 18 to 90 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: February 2024
See protocol details

Summary

Principal SponsorHe Eye Hospital
Study ContactGuanghao QinMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 22, 2024

Actual date on which the first participant was enrolled.

This study focuses on understanding how Intense Pulsed Light (IPL) treatment can help people with dry eye disease, particularly those caused by Meibomian gland dysfunction (MGD), which is a common form of dry eye. Dry eye can cause symptoms like eye pain, blurry vision, and tear film problems, often due to factors like aging, menopause, or certain medications. IPL has been used for skin conditions and is now being explored as a treatment for dry eye, potentially helping by reducing inflammation and improving tear quality. This study is important as it aims to evaluate the effectiveness of IPL in treating dry eye by looking at levels of a protein called Lymphotoxin-alpha (LTA) in tears, which might be a marker for dry eye severity and treatment response. In the study, participants with dry eye will receive IPL treatment. Researchers will collect tear samples to measure levels of LTA before and after the IPL sessions, using a special test designed to be quick and easy to use. This will help to see if the treatment affects the amount of LTA, providing insight into how IPL might help reduce dry eye symptoms. The study does not list specific risks or benefits but aims to provide clearer evidence for using IPL as a treatment option, potentially offering a more practical approach for managing dry eye in clinical settings.

Official TitlePoint of Care Test of LTA Level in Tear Fluid, Measured With a POCT Test, in DE Patients Following IPL Treatment
Principal SponsorHe Eye Hospital
Study ContactGuanghao QinMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 90 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Eye DiseasesLacrimal Apparatus DiseasesDry Eye Syndromes

Criteria

4 inclusion criteria required to participate
age ≥ 18 years

Fitzpatrick skin types I to IV

capable and willing to comply with the treatment and follow-up obligations

a determination of DED based on (a) the Ocular Surface Disease Index (OSDI) ≥13 score represents severe DED, (b) non-invasive tear film breakup time (NITBUT) of ≤5 sec, or conjunctivocorneal staining score (CS) ≥3 points according to the Japanese Dry Eye Consensus

5 exclusion criteria prevent from participating
Existing ocular trauma, infectious diseases, recent surgical history

Skin defects, pigmentation, moles, scars in the treatment area, skin cancer

Autoimmune diseases, skin allergies.

Pregnancy or lactation

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Participants in the group with 3 sessions of IPL, 2 weeks apart.

Group II

Sham
Participants in the group with 2 sessions of IPL, 1 session of sham IPL, 2 weeks apart.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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