Different Treatment Approaches of Presumed Trematode-Induced Uveitis
Surgical removal
Eye Diseases
+ Uveal Diseases
+ Uveitis
Treatment Study
Summary
Study start date: October 21, 2023
Actual date on which the first participant was enrolled.This study focuses on exploring different treatment approaches for a rare eye condition known as trematode-induced uveitis. Trematodes are parasitic flatworms that can cause inflammation in the eye by migrating into it, leading to sight-threatening issues. The presence of pearl-like nodules in various parts of the eye often characterizes this condition. Despite its rarity, trematode-induced uveitis is challenging to diagnose and treat. The study is crucial as it aims to evaluate different treatment methods, providing insights that could help eye specialists manage this complex condition more effectively. Participants in this study will be exposed to various treatment options, including antiparasitic medications, steroid therapy, surgery, and laser therapy. Antiparasitic medications aim to kill the parasites, although their effectiveness varies and may have side effects. Steroid therapy, the standard treatment, reduces inflammation but does not address the parasitic cause and may lead to side effects like increased eye pressure. Surgery and laser therapy are considered for severe cases but carry their own risks. By comparing these treatments, the study seeks to identify the most effective and safest approach for managing trematode-induced uveitis.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.31 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: Clinical Presentation: Presence of Uveitis: Include patients with clinically diagnosed uveitis, characterized by inflammation of the uvea9. Suspicion of Trematode Etiology: Include cases where there is a reasonable suspicion or evidence suggesting trematode-induced uveitis based on clinical picture of pearl like whitish AC or subconjunctival nodules characteristic for this specific entity, history of swimming in local ponds and canals in endemic areas.10 Diagnostic Confirmation: Positive Diagnostic Findings: Include patients with characteristic clinical picture and exclusion of other causes of granulomatous uveitis by appropriate laboratory tests and imaging modalities.11 Severity of Uveitis: Disease scores at presentation for parasitic granulomatous uveitis Parameter range score Diameter of AC lesion \>3mm 1 3-5mm 2 \<5mm 3 Grade of AC inflammation +.5 to+1 1 * 2 to +3 2 * 4 3 Complications at presentation none 0 Retro corneal scar or corectopia 1 Cataract 2 Glaucomatous optic atrophy 3 Eyes with scores \> 5 were started on steroid therapy. Patients with severity scores \<= 5at presentation were advised for surgical excision of the AC lesions. Based on SUN grading scheme for AC cells. Age and Gender: All Ages: Consider including patients of all age groups. Both Genders: Include both males and females Exclusion Criteria: Alternative Diagnoses: Presence of Other Ocular Diseases: Exclude patients with other causes of uveitis12. Concomitant Systemic Infections: Exclude patients with concomitant systemic infections that may independently cause uveitis. Patients unwilling to participate in the study Treatment History: Previous Treatment for Trematode-Induced Uveitis: Exclude patients who have previously undergone treatment specifically for trematode-induced uveitis13. Non-Compliance: Exclude patients with a history of non-compliance with prescribed treatments. Contraindications to Specific Treatments: Contraindications to Medications: Exclude patients with known contraindications to specific antiparasitic medications or corticosteroids. Ineligibility for Surgery: Exclude patients who are not suitable candidates for surgical interventions14. Pregnancy and Lactation: Pregnant or Lactating Women: Consider excluding pregnant or lactating women due to potential risks associated with certain treatments15
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location