Personalized Brain Functional Sector-guided rTMS Therapy Over Different Targets for Treatment-resistant Depression

The study focuses on improving treatment for individuals with depression who have not responded well to standard therapies. It examines the use of a therapy called repetitive transcranial magnetic stimulation (rTMS), which stimulates specific parts of the brain, specifically the dorsolateral and ventromedial prefrontal cortex areas. These areas are linked with mood regulation, and their precise stimulation may help relieve symptoms of depression. The research aims to determine the most effective brain targets for rTMS to ensure better outcomes for patients. By identifying personalized targets within the brain, the study hopes to enhance the effectiveness of depression treatments and address the limitations of current therapies. Participants in the study will first go through a screening process to confirm they are eligible. Once selected, they will begin treatment, which involves receiving rTMS therapy targeting one of 40 specific sites in the brain over a two-week period. The treatment does not involve surgery or medication changes, as participants will maintain their usual treatment routines during the study. To assess the therapy's impact, patients will be monitored during the treatment and for a week after the treatment ends. The study is carefully designed to ensure safety and to explore how different brain sites respond to the therapy, thus aiding in the development of more effective and personalized interventions for treating depression.