Completed

ExStressEffects of Exercise Intensity on Stress-Related Biological and Psychological Outcomes

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Study Aim

This study aims to observe how different intensities of exercise can impact stress-related biological and psychological outcomes, focusing on changes in blood flow in the brain's prefrontal cortex.

What is being tested

Seated rest

+ Exercise at moderate intensity

+ Exercise at vigorous intensity

Behavioral
Who is being recruted

Neuroinflammatory Diseases+5

+ Behavior

+ Behavioral Symptoms

From 20 to 40 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: February 2024
See protocol details

Summary

Principal SponsorThe Swedish School of Sport and Health Sciences
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 15, 2024

Actual date on which the first participant was enrolled.

This study aims to explore how physical exercise of different intensities affects people experiencing mild stress symptoms compared to healthy individuals. It involves 43 adults aged 20 to 40 years who have stress-related symptoms and another 43 healthy adults matched by age, sex, and fitness level. Understanding the influence of exercise on biological and psychological outcomes could potentially improve stress management and overall mental well-being. This study is important as it targets an area where exercise might help alleviate stress, offering an accessible and non-pharmacological intervention. Participants will undergo three different sessions, each a week apart: moderate-intensity cycling, vigorous-intensity cycling, and a session of seated rest. Before starting, participants will be tested for their maximum oxygen uptake to tailor the exercise intensity to their fitness levels. During each session, participants perform memory tasks before and after exercise, while researchers measure brain activity, blood flow, and take blood samples to assess various health markers. Additionally, mood and fatigue levels, heart rate, and blood pressure are monitored, along with sleep quality before and after the sessions. This comprehensive approach helps to understand the immediate effects of exercise on stress and health indicators in both stressed and healthy individuals.

Official TitleAcute Effects of Physical Exercise of Different Intensities on Biological and Psychological Outcomes Under Subclinical Stress and in Health
NCT06245538
Principal SponsorThe Swedish School of Sport and Health Sciences
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

24 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 20 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Neuroinflammatory DiseasesBehaviorBehavioral SymptomsInflammationNervous System DiseasesPathologic ProcessesStress, PsychologicalPathological Conditions, Signs and Symptoms

Criteria

5 inclusion criteria required to participate
Participants experiencing sub-clinical levels of stress-related symptoms:

Age: 20-40 years

Absence of contraindications to physical exercise

Do not participate in any other study

Show More Criteria

8 exclusion criteria prevent from participating
Alcohol abuse

Medical contraindication to catheterization of the antecubital vein and blood sampling

Dementia

Smoking

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants will be resting while seated on a comfortable chair for 20 minutes

Group II

Experimental
Participants will perform a 20-min leg cycling exercise on a cycle ergometer at moderate intensity (60% of VO2max)

Group III

Experimental
Participants will perform a 20-min leg cycling exercise on a cycle ergometer at vigorous intensity (80% of VO2max)

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The Swedish School of Sport and Health Sciences

Stockholm, SwedenOpen The Swedish School of Sport and Health Sciences in Google Maps
CompletedOne Study Center