Completed

Assessment of Flurbiprofen Tablet and Spray For Postoperative Pain Control In Oral Soft Tissue Wounds: A Randomized Clinical Trial

What is being tested

Flurbiprofen

Drug

Who is being recruted

From 40 to 65 Years

+2 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Treatment Study

Phase 4

Interventional

Study Start: October 2023

See protocol details

Summary

Principal SponsorYuzuncu Yil University

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: October 26, 2023

Actual date on which the first participant was enrolled.

This study investigates how effective flurbiprofen tablets and spray are in managing pain after dental surgery involving soft tissue wounds. It involves patients who need to have certain oral tissues, like epulis fissuratum or frenulum, removed as part of preprosthetic surgery. The study is important because it aims to find the best way to relieve pain after these surgeries, which can help improve recovery and comfort for patients undergoing similar procedures. Participants are divided into two groups randomly, with one group receiving flurbiprofen in tablet form and the other in spray form, following their surgery. Both groups also receive paracetamol and a special mouthwash as additional pain relief options. The study monitors how well each form of flurbiprofen controls postoperative pain. The tissue pieces removed during surgery are examined to confirm the condition. This approach helps ensure that the pain management methods are tested accurately and that the participants' recovery process is closely observed.

Official TitleAssessment of Flurbiprofen Tablet and Spray For Postoperative Pain Control In Oral Soft Tissue Wounds: A Randomized Clinical Trial

NCT06238154

Principal SponsorYuzuncu Yil University

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 40 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate

Provided that those using removable prosthesis had discontinued using the prosthesis 1 month ago (in order to minimize the lesion to be excised), healthy or ASA Class I patients between 40 and 65 years of age, who had the indication of pre-prosthetic surgery due to excision of epulis fissuratum and frenulum

1 exclusion criteria prevent from participating

Pregnancy, lactation, and taking contraceptive pills; being allergic to the drug or other NSAIDs to be used in the study; had used steroids or analgesic drugs for any reason for the last 1 month; using psychiatric drugs; those with incomplete data and refused to sign the consent form; those who were extremely afraid and had a gag reflex; those with any gastrointesinal problems; smoking, ASA-2 and ASA-3 patients and those who smoked.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Experimental

Spray group consisted of individuals who used flurbiprofen in spray form as a postoperative analgesic

Group II

Active Comparator

Tablet group consisted of individuals who used flurbiprofen in tablet form as a postoperative analgesic

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Yuzuncu Yil University

Van, Turkey (Türkiye)Open Yuzuncu Yil University in Google Maps

CompletedOne Study Center