Clinical Evaluation of the Improvement in Bioavailability of Four Magnesium-based Products in 40 Human Volunteers After an Oral Intake by Assessing Magnesium Absorption Kinetics in Plasma for 8 Hours

This study aims to understand how well the body absorbs different forms of magnesium when taken as supplements. Magnesium is a vital nutrient needed for many body functions, including the creation of DNA and energy production. Many people do not get enough magnesium in their diet, so this research could help determine which magnesium supplements are most effective in improving magnesium levels in the body. The study involves 40 healthy volunteers aged between 20 and 55 years who will help researchers compare four types of magnesium supplements: Microencapsulated Magnesium, Magnesium Oxide, Magnesium Citrate, and Magnesium Bisglycinate. Participants will follow a special low-magnesium diet for a week before starting the test. On the test day, after fasting for 8 hours, a small blood sample will be taken from their finger, and they will then take one of the magnesium supplements orally. Blood samples will be collected at several intervals over the next 8 hours to measure the magnesium in their blood. Each participant will repeat this process for each of the four magnesium products over four weeks. The study ensures that meals and water intake are controlled to maintain consistent conditions. Blood testing is done in a non-invasive manner, and the results will help determine which supplement is most readily absorbed by the body.