CNF-RNTModulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression

This study focuses on young adults aged 18 to 25 who suffer from major depressive disorder (MDD). One in ten young adults are affected by MDD, which can lead to serious consequences like related mental disorders, unemployment, and even suicide. The study aims to explore a new approach to treatment by targeting repetitive negative thinking (RNT), a common issue in MDD where individuals struggle to control distressing thoughts. Current treatments such as medication and therapy often have limited success, particularly for those with high levels of RNT. By using real-time functional Magnetic Resonance Imaging neurofeedback (rtfMRI-nf), the study seeks to understand and potentially modify the brain activity associated with these distressing thought patterns, which could lead to better recovery outcomes for those with MDD. Participants in this study will undergo a non-invasive brain imaging technique that provides real-time feedback on their brain activity. The study involves 110 young adults with MDD and high levels of RNT, who will be randomly assigned to receive either real feedback on their brain activity or sham feedback that does not relate to their brain activity. This will be done during a self-regulation task across two visits one week apart. The primary goal is to see if the real feedback can reduce abnormal brain connectivity linked to RNT, potentially decreasing the severity of negative thinking and depression. The study will measure changes in brain connectivity and evaluate the impact on depression and negative thinking severity using established rating scales.