Recruiting

ACT for CABGAcceptance and Commitment Therapy for the Perioperative Period of Coronary Artery Bypass Graft Surgery: a Randomized Controlled Feasibility Trial

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What is being tested

Acceptance and commitment therapy

Behavioral
Who is being recruted

Arterial Occlusive Diseases+9

+ Arteriosclerosis

+ Cardiovascular Diseases

From 18 to 80 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: February 2024
See protocol details

Summary

Principal SponsorUniversity of Iowa
Study ContactSara J Diesel, MAMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 12, 2024

Actual date on which the first participant was enrolled.

This study focuses on helping patients who are undergoing coronary artery bypass graft (CABG) surgery, a procedure often needed when medications aren't enough to manage heart disease symptoms such as chest pain. Heart disease is a leading cause of death and carries a high economic cost. CABG can be lifesaving, but it also tends to increase inflammation and is associated with high levels of anxiety and depression around the time of surgery. These emotional challenges can worsen health outcomes and increase healthcare costs. The study aims to explore the use of Acceptance and Commitment Therapy (ACT), a type of psychological therapy, during the surgical period to help improve mental well-being and potentially improve physical health outcomes for these patients. Participants in this study are randomly assigned to one of two groups. One group receives a brief, two-session ACT therapy via telehealth, while the other group continues with their usual care without the additional therapy. The study measures the feasibility of delivering this therapy around the time of surgery and evaluates its preliminary effectiveness. Researchers look at various factors, including levels of anxiety, depression, overall well-being, and the quality of life related to heart health. They also check for changes in inflammation by measuring specific markers in the body. The findings could guide future, larger studies to support heart surgery patients better.

Official TitleAcceptance and Commitment Therapy for the Perioperative Period of Coronary Artery Bypass Graft Surgery: a Randomized Controlled Feasibility Trial
NCT06207318
Principal SponsorUniversity of Iowa
Study ContactSara J Diesel, MAMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 80 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arterial Occlusive DiseasesArteriosclerosisCardiovascular DiseasesCoronary Artery DiseaseCoronary DiseaseHeart DiseasesMetaplasiaNeovascularization, PathologicPathologic ProcessesPathological Conditions, Signs and SymptomsVascular DiseasesMyocardial Ischemia

Criteria

4 inclusion criteria required to participate
admission to the Heart and Vascular Center at University of Iowa Hospitals and Clinics (UIHC) for urgent or elective CABG

access to a personal phone or device with video or audio capabilities

ability to provide informed consent

English fluency.

5 exclusion criteria prevent from participating
life-threatening comorbid (noncardiac) medical condition(s)

active suicidal ideation or intent

psychotropic medication use lasting less than four weeks

inability to provide informed consent and comply with study procedures

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants in the ACT Intervention condition will receive a two-session intervention, with each session lasting 60-90 minutes. Intervention content will center around personal values and behaviors that align with participant goals and utilize the 'triflex' model of ACT, which indicates three core processes of psychological flexibility: be present, open up, and do what matters. Sessions will be facilitated by the PI, an advanced graduate student in the Clinical Science Ph.D. program at the University of Iowa trained in ACT psychotherapy and supervised by a licensed and highly experienced psychologist. Patients will receive a patient workbook and audio recordings of mindfulness exercises that mirror those completed during the session. The intervention will also focus on patients' health-related goals and objectives surrounding their surgery, and expectations for positive post-surgical functioning.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

University of Iowa Hospitals and Clinics

Iowa City, United StatesOpen University of Iowa Hospitals and Clinics in Google Maps
Recruiting
One Study Center