Completed

Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes

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What is being tested

Sodium Monofluorophosphate

+ Stannous Fluoride

+ Nano-Hydroxyapatite

Other
Who is being recruted

Dentin Sensitivity

+ Stomatognathic Diseases

+ Tooth Diseases

From 18 to 65 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: May 2022
See protocol details

Summary

Principal SponsorAltinbas University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2022

Actual date on which the first participant was enrolled.

Dentin hypersensitivity is a condition where the teeth become sensitive to hot or cold stimuli, affecting many people and leading to discomfort and potential dental issues over time. This study focuses on finding out how effective different types of desensitizing toothpastes are in reducing this sensitivity. The study targets adults who have at least two teeth experiencing this sensitivity. By comparing various toothpastes, such as those containing sodium fluoride, stannous fluoride, nano-hydroxyapatite, and a combination of arginine and calcium carbonate, the study aims to identify which toothpaste might provide the best relief. Understanding the effectiveness of these products can help improve daily life for those affected by dentin hypersensitivity and reduce the risk of related dental problems. Participants in the study are divided into four groups, each using a different type of toothpaste for a period of 16 weeks. The toothpastes are applied as part of their regular oral hygiene routine. The study evaluates the level of dentin hypersensitivity at the start, and then at the 2nd, 4th, and 16th weeks using specific scoring methods like VAS and Shiff scores, along with checking periodontal health. There are no specific risks noted, but the study's benefits could include finding a more effective way to manage tooth sensitivity, improving comfort and dental health in the long term.

Official TitleComparision of the Clinical Efficacy of Different Desensitizing Toothpastes
NCT06197555
Principal SponsorAltinbas University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

48 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dentin SensitivityStomatognathic DiseasesTooth Diseases

Criteria

Inclusion Criteria: * Dentin hypersensitivity complaints * Systemically healthy * Not during pregnancy \& lactation * No sensitivity treatment in the last 6 months * Forty-eight patients with positive response to VAS and Schiff tests were included. Exclusion Criteria: People who have; * Any systemic disease * Take regular medication for any other reason * Undergone periodontal surgery within the last 6 months, * History of allergy to toothpaste materials, * Active caries, restoration and/or bridge on the sensitive tooth, * Orthodontic appliances,

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Dentifrice containing Sodium Monofluorophosphate, daily homecare usage Colgate®, Cavity Protection

Group II

Active Comparator
Dentifrice containing Stannous Fluoride, daily homecare usage Oral B®, Gum Calm \& Sensitivity

Group III

Active Comparator
Dentifrice containing Nano-Hydroxyapatite, daily homecare usage ApaCare®

Group IV

Active Comparator
Dentifrice containing 8% Arginine \& Calcium Carbonate, daily homecare usage Colgate®, Sensitive Pro-Relief

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Altinbas University

Istanbul, Turkey (Türkiye)Open Altinbas University in Google Maps
CompletedOne Study Center