Completed

The Change of Subfoveal Choroidal Thickness After Intravitreal Injection of Ranibizumab and Its Correlation With Visual Acuity in Diabetic Retinopathy

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What is being tested

Intravitreal injection of ranibizumab

Procedure
Who is being recruted

Cardiovascular Diseases+6

+ Diabetes Mellitus

+ Diabetic Angiopathies

From 50 to 70 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: February 2021
See protocol details

Summary

Principal SponsorEgyptian Biomedical Research Network
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2021

Actual date on which the first participant was enrolled.

This study focuses on understanding changes in a part of the eye called the choroid in people with diabetic retinopathy, a condition that affects vision in those with diabetes. The choroid is important because it supplies blood to the outer part of the retina. Researchers are interested in seeing how the thickness of the choroid changes after a specific eye injection called Ranibizumab, and how these changes relate to vision quality. Diabetic retinopathy can lead to vision loss, and this study aims to find better ways to monitor and potentially improve visual outcomes for these patients. Participants in the study receive an injection of Ranibizumab directly into the eye, a common treatment method for eye conditions. To measure the effects of this treatment, researchers use a technique called Optical Coherence Tomography (OCT), which takes detailed images of the eye. Enhanced Depth Imaging OCT allows for a closer look at the choroid to see how its thickness changes after the injection. Although the study does not list specific outcomes, the focus is on understanding how these changes might impact vision, potentially leading to improved treatments for diabetic eye disease.

Official TitleThe Change of Subfoveal Choroidal Thickness After Intravitreal Injection of Ranibizumab and Its Correlation With Visual Acuity in Diabetic Retinopathy
NCT06173245
Principal SponsorEgyptian Biomedical Research Network
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

50 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 50 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cardiovascular DiseasesDiabetes MellitusDiabetic AngiopathiesDiabetic RetinopathyEndocrine System DiseasesEye DiseasesRetinal DiseasesVascular DiseasesDiabetes Complications

Criteria

3 inclusion criteria required to participate
Age from 50 to 70 years.

Both sexes.

Patients suffering from diabetic macular edema (DME).

2 exclusion criteria prevent from participating
High myopia more than 6 diopters.

previous injections or retinal surgery.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
These patients were received three intravitreal injection of ranibizumab with one month interval.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Al-Azhar University

Asyut, EgyptOpen Al-Azhar University in Google Maps
CompletedOne Study Center