IncipientEffect of Vitamin D Supplementation on Salivary Biomarkers; Certain Proteins and Cariogenic Oral Microbiome for Medical Management of Dental Caries: A Randomized Controlled Trial

This study explores the impact of vitamin D supplementation on dental health, particularly focusing on salivary proteins and bacteria that cause tooth decay. The research targets individuals aged 12 to 45 who are at moderate risk for dental cavities and have a deficiency in vitamin D. Participants must also have at least two teeth with early signs of cavities. The goal is to understand if supplementing vitamin D can help manage dental caries by influencing the proteins in saliva and reducing harmful oral bacteria. This is important because improving vitamin D levels might offer a new way to prevent or manage dental cavities, which are a common health issue. Participants are randomly divided into three groups for a six-month period. Group A gets vitamin D supplements and oral hygiene advice; Group B receives vitamin D supplements, fluoride treatments, and oral hygiene advice; and Group C, the control group, receives fluoride treatments and oral hygiene advice without vitamin D supplements. The study evaluates changes in cavity severity, levels of certain proteins in saliva, and the number of cavity-causing bacteria. These results help determine whether vitamin D supplements can positively affect dental health and reduce the risk of cavities.