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Resonant Voice Therapy for Phonotraumatic Vocal Lesions

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Study Aim

This study aims to evaluate how effective resonant voice therapy is in reducing the severity of vocal fold lesions and improving the voice handicap in individuals with phonotraumatic vocal lesions.

What is being tested

Resonant voice therapy

Behavioral
Who is being recruted

From 18 to 40 Years
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: December 2025
See protocol details

Summary

Principal SponsorUniversity of California, Los Angeles
Study ContactZhaoyan Zhang
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 1, 2025

Actual date on which the first participant was enrolled.

This study focuses on understanding how a voice therapy technique known as resonant voice therapy can help in reducing the pressure on vocal cords, especially in adults who have certain types of vocal cord lesions caused by voice misuse or overuse. These lesions, known as phonotraumatic lesions, can cause discomfort and affect voice quality. The study aims to see if this therapy can make physical changes in the throat and vocal cords that result in less pressure on the vocal cords. This is important because reducing this pressure might lead to better voice quality and less strain, which could improve overall vocal health for people with these lesions. Participants in the study are adults who have been diagnosed with specific types of vocal cord lesions and are referred for resonant voice therapy, which is a standard treatment for such conditions. The therapy involves weekly sessions over four weeks, where participants engage in exercises that help them use their voice in a way that reduces strain. Throughout the study, various measurements are taken, such as pressure on the vocal cords, and participants also complete a questionnaire about how their voice affects their daily life. These assessments are done before therapy begins, immediately after the first session, and after completing all sessions to see how the therapy helps over time. The study also involves using scans and video recordings to observe any physical changes in the throat during speaking, ensuring accurate evaluation of the therapy's impact on vocal health.

Official TitleLaryngeal and Vocal Tract Strategies to Reduce Vocal Fold Contact Pressure
NCT06165536
Principal SponsorUniversity of California, Los Angeles
Study ContactZhaoyan Zhang
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

Inclusion Criteria: * Ages 18-40 years (to minimize developmental changes associated with adolescent and elderly age) * Clinic diagnosis by a fellowship trained laryngologist of mid-membranous lesions that by history and appearance are phonotraumatic * Must be referred for voice therapy Exclusion Criteria: * Medical comorbidities (e.g., autoimmune disorders) beyond seasonal allergy and laryngopharyngeal reflux * Vocal fold lesions generally regarded to be less responsive to voice therapy (e.g. vocal fold cysts). * Claustrophobia * Inability to replicate fundamental frequencies required for the study at the intensity levels determined

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Resonant voice therapy is a standard of care procedure for treating phonotraumatic vocal hyperfunction. The full standardized voice therapy program will have a duration of four weeks, each week with one 60-minute therapy session.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

UCLA Rehab Center

Los Angeles, United StatesOpen UCLA Rehab Center in Google Maps
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One Study Center