Efficacy of Physiological Saline and Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children Aged 2-5, in Son Tay Province, Hanoi

This study explores the potential of using a probiotic nasal spray to help prevent respiratory diseases in young children aged 2 to 5 years old. In Vietnam, children under 5 are particularly vulnerable to respiratory infections like pneumonia and bronchiolitis, especially during certain seasons. While there are vaccines for some respiratory infections, there are none for others like RSV and adenovirus, making prevention challenging. The study is crucial as it investigates whether using probiotics directly in the nose could be a safe and effective method to reduce the number of respiratory diseases in children, potentially minimizing the need for antibiotics and improving overall respiratory health. In this clinical trial, 600 children will be divided into three groups, with each group receiving different treatments. One group will use a saline nasal spray, while the other two groups will use probiotic nasal sprays: LiveSpo Navax or LiveSpo Navax Kid. The trial is double-blind, meaning neither the children nor the researchers know which treatment each child receives, ensuring unbiased results. Over four weeks, the children's health will be closely monitored, with regular check-ups and tests to see if the probiotics help reduce respiratory issues. Parents are asked to avoid giving their children other probiotics or nasal treatments during this period. The study measures the number of respiratory infections, the duration of illness, and any antibiotic use, aiming to provide clear insights into the effectiveness of the probiotic sprays.