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A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents

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What is being tested

TranS-C

+ Psychoeducation

Behavioral
Who is being recruted

Behavior

+ Behavioral Symptoms

+ Depression

From 12 to 18 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: March 2024
See protocol details

Summary

Principal SponsorUniversity of California, San Francisco
Study ContactLauren Asarnow, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 15, 2024

Actual date on which the first participant was enrolled.

This study focuses on helping teenagers who suffer from depression and have a mismatch between their internal body clock and the time they wake up. The researchers are interested in seeing if adjusting this relationship can lead to better outcomes for these young people. By targeting this specific aspect, the study aims to find new ways to aid adolescents struggling with depression, potentially providing a novel method for improving their mental health. Participants in the study will undergo a cognitive-behavioral sleep intervention, which is a structured program designed to improve sleep patterns and, in turn, mood. The intervention will involve strategies to help align their biological clock with a healthier waketime. Although the study doesn't specify how results will be measured, the goal is to assess if these changes lead to a noticeable improvement in depression symptoms. This research could offer valuable insights into a new avenue for treating depression in adolescents by focusing on their sleep and circadian rhythms.

Official TitleA Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents
NCT06139861
Principal SponsorUniversity of California, San Francisco
Study ContactLauren Asarnow, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 12 to 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorBehavioral SymptomsDepression

Criteria

4 exclusion criteria prevent from participating
mental health/behavioral symptoms that would preclude productive engagement in study assessments or intervention (e.g., active psychosis; Bipolar Disorder; drug dependence

severe or unstable medical or psychiatric condition such that treatment has changed within the last month or is expected to change during the course of the study or that would preclude ability to adhere to study procedures (e.g. terminal end-stage cancer)

current use of medications or herbs with known effects on sleep

plan to undergo or have had medication change in the last 8 weeks

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental

Group II

Active Comparator

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

UCSF Nancy Friend Pritzker Psychiatry Building

San Francisco, United StatesOpen UCSF Nancy Friend Pritzker Psychiatry Building in Google Maps
Recruiting
One Study Center