Completed

Greater Occipital Nerve Pulsed Radiofrequency for the Treatment of Combined Migraine and Cervicogenic Headache (New Approach): Randomized Clinical Trial

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What is being tested

proximal ultrasound-guided GON radiofrequency ablation

+ distal ultrasound-guided GON radiofrequency ablation

Procedure
Who is being recruted

From 18 to 65 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: January 2022
See protocol details

Summary

Principal SponsorAssiut University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2022

Actual date on which the first participant was enrolled.

This study explores a new way to help people who suffer from a combination of migraine and cervicogenic headaches, which are headaches that originate in the neck. Traditional treatments usually involve medications, but sometimes these don't work well enough. For those who have not found relief with drugs, there is growing interest in targeting the greater occipital nerve, a nerve involved in head and neck pain. This study is important because it investigates the use of radiofrequency ablation, a method that uses heat to disrupt pain signals, as a potential solution for those whose headaches don't respond to usual treatments. Participants in this study will receive treatment through a process called pulsed radiofrequency, which involves using ultrasound guidance to precisely target the greater occipital nerve. This procedure aims to lessen pain by interfering with the nerve's ability to send pain signals. The study will monitor how well this method works in providing relief from headaches. While the potential benefits include significant pain reduction, the study will also consider any risks associated with the procedure. The results could offer a new option for those struggling with chronic headaches that don't respond to standard treatments.

Official TitleGreater Occipital Nerve Pulsed Radiofrequency for the Treatment of Combined Migraine and Cervicogenic Headache (New Approach): Randomized Clinical Trial
Principal SponsorAssiut University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
Patients diagnosed with combined migraine and cervicogenic headache according to The International Classification of Headache Disorders (ICHD)

Age between 18 and 65 years.

Willingness to participate and provide informed consent

4 exclusion criteria prevent from participating
Previous neurosurgical procedures for headache management.

Patients with contraindications for the RF technique

Pregnancy or lactation

History of psychiatric disorders or substance abuse

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
proximal ultrasound-guided GON radiofrequency ablation

Group II

Experimental
distal ultrasound-guided GON radiofrequency ablation

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Assiut governorate

Asyut, EgyptOpen Assiut governorate in Google Maps
CompletedOne Study Center